Introduction：Basic information about L-Phenylglycine CAS 2935-35-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
L-Phenylglycine Basic information
| Product Name: | L-Phenylglycine |
| Synonyms: | H-PHG-OH;H-(PHENYL)GLY-OH;H-L-PHG-OH;(+)-L-ALPHA-PHENYLGLYCINE;L-(+)-ALPHA-PHENYLGLYCINE;L(+)-ALPHA-AMINOPHENYLACETIC ACID;L-ALPHA-AMINOPHENYLACETIC ACID;L-AMINOPHENYLACETIC ACID |
| CAS: | 2935-35-5 |
| MF: | C8H9NO2 |
| MW: | 151.16 |
| EINECS: | 220-909-8 |
| Product Categories: | Amino Acids;Phenylglycine [Phg];Unusual Amino Acids;Aromatic Phenylacetic Acids and Derivatives;GLYCINESCAFFOLD;Amino ACIDS SERIES |
| Mol File: | 2935-35-5.mol |
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L-Phenylglycine Chemical Properties
| Melting point | >300 °C(lit.) |
| alpha | 157 º (c=2, 2N HCl) |
| Boiling point | 273.17°C (rough estimate) |
| density | 1.2023 (rough estimate) |
| refractive index | 158 ° (C=1, 1mol/L HCl) |
| Fp | 150 °C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Aqueous Acid, Aqueous Base |
| pka | 1.83(at 25℃) |
| form | Fine Crystalline Powder |
| color | White |
| Optical Rotation | [α]20/D +155°, c = 1 in 1 M HCl |
| Merck | 14,7291 |
| BRN | 2208675 |
| Major Application | peptide synthesis |
| InChI | 1S/C8H9NO2/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H,10,11)/t7-/m0/s1 |
| InChIKey | ZGUNAGUHMKGQNY-ZETCQYMHSA-N |
| SMILES | N[C@H](C(O)=O)c1ccccc1 |
| CAS DataBase Reference | 2935-35-5(CAS DataBase Reference) |
| EPA Substance Registry System | L-Phenylglycine (2935-35-5) |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HS Code | 29224995 |
| Storage Class | 11 - Combustible Solids |
L-Phenylglycine Usage And Synthesis
| Description | L-Phenylglycine is an amide that belongs to the group of pyridoxal phosphate analogues. It has been shown to be a response element for enzymes and natural compounds in Escherichia coli and Saccharomyces cerevisiae. It inhibits aminotransferase activity, dopamine synthesis, and microbial metabolism in these organisms. This compound also has a structural analysis that includes x-ray diffraction data, which can be used to identify its three-dimensional structure. |
| Chemical Properties | White crystalline powder |
| Uses | L-(+)-2-Phenylglycine is a derivative of Glycine (G615990), the smallest of all the amino acids, and is also used to treat schizophrenia, stroke, and benign prostatic hyperplasia. L-(+)-2-Phenylglycine is also used as an N-linked side chain of an SMTP (Stachybotrys microspora tripenyl phenols) congener, which was potent in enhancing plasminogen activation in S. microspora. |
| Definition | ChEBI: The S stereoisomer of alpha-phenylglycine. |
| reaction suitability | reaction type: solution phase peptide synthesis |
| Purification Methods | Crystallise it from EtOH. [Kaneko J Chem Soc Jpn 60 538 1939, Rudman et al. J Am Chem Soc 74 551 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2694-2697 1961, Beilstein 14 III 1187, 14 IV 1317.] |
L-Phenylglycine Preparation Products And Raw materials
| Raw materials | Sodium cyanide-->Benzaldehyde-->Salicylaldehyde-->DL-10-CAMPHORSULFONIC ACID |
| Preparation Products | L-alpha-Cyclohexylglycine-->(S)-(+)-N-(3,5-DINITROBENZOYL)-ALPHA-PHENYLGLYCINE-->(S,S)-2,2'-METHYLENEBIS(4-PHENYL-2-OXAZOLINE)-->2-([(4-CHLOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID-->(2S,3'S)-N-3-HYDROXYPYRROLIDIN-PHENYL-GLYCINAMIDE-->(+)-N-TRIFLUOROACETYL-L-PHENYLGLYCINE |
