Introduction：Basic information about LUPENONE CAS 1617-70-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
LUPENONE Basic information
| Product Name: | LUPENONE |
| Synonyms: | Aids-082905;LUPENONE;18-LUPEN-3-ONE;-en-3-one;Lup-20(29);LUPENONE(RG);5α-Lup-20(29)-en-3-one;Lup-20(29)-en-3-one |
| CAS: | 1617-70-5 |
| MF: | C30H48O |
| MW: | 424.7 |
| EINECS: | |
| Product Categories: | Building block |
| Mol File: | 1617-70-5.mol |
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LUPENONE Chemical Properties
| Melting point | 165-167°C |
| Boiling point | 485.7±14.0 °C(Predicted) |
| density | 1.115 g/cm3(Temp: 18 °C) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White |
| LogP | 10.400 (est) |
Safety Information
| Hazard Codes | Xi |
| HS Code | 29142990 |
LUPENONE Usage And Synthesis
| Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dandelion, bamboo leaves and Adenophora australis. |
| Uses | Lupenone is a lupane triterpenoid with antioxidant and anticholinesterase activity. It also a potential protein tyrosine phosphatase 1B (PTP1B) inhibitor. |
| Definition | ChEBI: A natural product found in Cupania cinerea. |
| in vivo | Lupenone (6, 12, 24 mg/kg/day, gavage for 6 weeks) improves type 2 diabetic nephropathy by regulating NF-κB pathway-mediated inflammation and TGF-β1/Smad/ CTGF-related fibrosis[2].
| Animal Model: | Spontaneous type 2 diabetic nephropathy db/db mouse models[1] | | Dosage: | 6, 12, 24 mg/kg | | Administration: | i.g. | | Result: | Maintained the fasting blood glucose.
Reduced glycosylated hemoglobin, insulin, and 24 h proteinuria levels.
Regulated changes in biochemical indicators |
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| IC 50 | Trypanosoma |
LUPENONE Preparation Products And Raw materials
