Maneb CAS 12427-38-2
Introduction：Basic information about Maneb CAS 12427-38-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Maneb Basic informationPreparation
| Product Name: | Maneb |
| Synonyms: | MULTI-W FL;POLICRITT;TRIMANGOL;((1,2-ethanediylbis(carbamodithioato))(2-))-manganes;MEB;MAZIN;MANZATE;Manganese(Ⅱ)ethylenebis(dithiocarbamate) |
| CAS: | 12427-38-2 |
| MF: | C4H6MnN2S4 |
| MW: | 265.3 |
| EINECS: | 235-654-8 |
| Product Categories: | Agro-Products;Heterocycles;Fungicide;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds |
| Mol File: | 12427-38-2.mol |
Maneb Chemical Properties
| Melting point | 131°C |
| density | 1.92 g/cm3(Temp: 25 °C) |
| vapor pressure | Negligible at 20 °C |
| storage temp. | 0-6°C |
| Water Solubility | Insoluble in water |
| form | solid |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| Merck | 13,5743 |
| BRN | 3747585 |
| Major Application | agriculture environmental |
| InChI | 1S/C4H8N2S4.Mn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);/q;+2/p-2 |
| InChIKey | YKSNLCVSTHTHJA-UHFFFAOYSA-L |
| SMILES | S=C1NCCNC(=S)S[Mn]S1 |
| CAS DataBase Reference | 12427-38-2(CAS DataBase Reference) |
| IARC | 3 (Vol. 12, Sup 7) 1987 |
| EPA Substance Registry System | Maneb (12427-38-2) |
Safety Information
| Hazard Codes | Xi,N,Xn |
| Risk Statements | 20/21/22-43-37-50/53-36-20-63 |
| Safety Statements | 22-36/37/39-46-24/25-8-61-60-36/37 |
| RIDADR | 2210 |
| WGK Germany | 1 |
| RTECS | OP0700000 |
| TSCA | No |
| HazardClass | 4.2 |
| PackingGroup | III |
| Storage Class | 4.2 - Pyrophoric and self-heating hazardous materials |
| Hazard Classifications | Acute Tox. 4 Inhalation Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Repr. 2 Skin Sens. 1 |
| Hazardous Substances Data | 12427-38-2(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: 3gm/kg |
| Preparation | Manganese ethylenebis(thiocarbamate) is made by adding disodium ethylenebis( dithiocarbamate) (also, known as Nabam, commercially available) to an aqueous solution of manganese(II) sulfate: NaSC(=S)NHCH2CH2NHC(=S)SNa + MnSO4 → C4H6MnN2S4 + Na2SO4 Alternatively, the compound may be prepared by neutralizing an aqueous solution of disodiummethylenebis(dithiocarbamate) (Nabam) with acetic acid followed by addition of manganese(II) chloride solution. |
| Description | Maneb is a pesticide with fungicide properties andbelongs to the carbamate (bis-dithiocarbamate) group.Sensitization occurs mainly in farmers and agriculturalworkers. |
| Chemical Properties | Brown powder. Decomposes on heating.Partially soluble in water; soluble in chloroform. |
| Chemical Properties | Maneb is a yellow powder or crystalline solidwith a faint odor. |
| Uses | Maneb is a contact fungicide that provides protection against awide variety of fungal diseases (including leaf spots, blight, rust, downymildew, scab, etc.) in field crops, fruits, vines, vegetables, ornamentals,potatoes, turf, berries and forestry. |
| Uses | Maneb is a complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. Maneb is a foliate fungicide used to protect crops in agriculture. Maneb is also useful in creating a toxin-based animal (usually primates) model of Parkinson's disease. |
| Definition | ChEBI: A polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. An agrochemical fungicide, it is used to control a variety of diseases including blight, leaf spot, rust, downy mildew and scab. |
| General Description | Maneb is a yellow powder or crystalline solid. Maneb is denser than water. Contact may irritate skin, eyes and mucous membranes. Maneb may be toxic by ingestion. Likely to generate heat spontaneously upon exposure to air or water. May be sufficient to ignite the material. Maneb is used as a fungicide. Formulations of Maneb include mixing Maneb with many other chemicals such as sulfur, zinc oxide and others to desensitize it. This is done to make Maneb easer for application. |
| Air & Water Reactions | Highly flammable. Soluble in water. Maneb is likely to generate heat spontaneously, especially when wet. The heat may be sufficient to ignite the material. Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids. |
| Reactivity Profile | The BPS Pesticide incident in Helena resulted in an explosion and death of three firemen. The burning of a 1,000 pound sack of Azinphos Methyl or the flashing of Maneb which was present on the facility may have caused the explosion. |
| Health Hazard | Fire will produce irritating, corrosive and/or toxic gases. Inhalation of decomposition products may cause severe injury or death. Contact with substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution. |
| Fire Hazard | Flammable/combustible material. May ignite on contact with moist air or moisture. May burn rapidly with flare-burning effect. Some react vigorously or explosively on contact with water. Some may decompose explosively when heated or involved in a fire. May re-ignite after fire is extinguished. Runoff may create fire or explosion hazard. Containers may explode when heated. |
| Agricultural Uses | Fungicide: Maneb is an ethylene(bis)dithiocarbamate fungicideused in the control of early and late blights on potatoesand tomatoes and many other diseases of fruits, vegetables,field crops, and ornamentals. Maneb controls a widerrange of diseases than other fungicides. It is availableas granular, wettable powder, flowable concentrate, andready-to-use formulations. Maneb is widely used by itselfand in combination with other pesticides on a variety ofcrops. Principal uses in California are for head and leaflettuce, walnuts, almonds, onions, potatoes and broccoli. |
| Trade name | (The U.S. EPA lists more than 460 active and/or canceled products containing maneb) AAMANGAN®;AKZO CHEMIE MANEB®; BASF-MANEBSPRITZPULVER®; BAVISTIN M®; COSMIC®; CHEMNEB®; CHLOROBLE M®; CLEANACRES®; CR 3029®;DELSENE M FLOWABLE®; DITHANE-22®; F 10®;FARMANEB®; IDA MANEB®; KASCADE®; KYPMAN80®; LONOCOL M®; MANAM®; MANEB 80®;MANEBA®; MANEBE®; MANEBGAN®; MANESAN®;MANESAN®; MANEX®; MANOC®; MANZATE®;MANZATE D®; MANZATE MANEB FUNGICIDE®;MANZEB®; MANZI®; M-DIPHAR®; MULTI-W®;NEREB®; NESPOR®; NEWSPOR®; PLANTIFOG160 M®; POLYRAM M®; REMASAN CHLOROBLEM®; RHODIANEHE®; SOPRANEBE®; SQUADRONAND QUADRANGLE MANEX®; SUPERMAN MANEBF®; SUP'R FLO®; TERSAN-LSR®; TRIMANGOL®;TRIMANOC®; TRITHAC®; TUBOTHANE®; UNICROPMANEB®; VANCIDE®; VANCIDE MANEB 80®;VASSGRO MANEX®; VITAVAX® Maneb |
| Contact allergens | Maneb is a pesticide with fungicide properties, belong-ing to the dithiocarbamate group. Sensitization occursmainly in farmers and agricultural workers. |
| Safety Profile | Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. A fungcide. May ignite spontaneously in air. When heated to decomposition it emits highly toxic fumes of NOx and SOx. See also MANGANESE COMPOUNDS and CARBAMATES. |
| Potential Exposure | A potential danger to those involvedin manufacture, formulation, and application of this broadspectrum dithiocarbamatefungicide. Some dithiocarbamateshave been used as rubber components. DFG warns of danger of skin sensitization. The BPS Pesticide incident inWest Helena, AK resulted in an explosion and death ofthree firemen. The burning of a 1000-lb sack of AzinphosMethyl or the flashing of Maneb which was present on thefacility may have caused the explosion |
| First aid | If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, 1660 Maneb including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. |
| Metabolic pathway | Maneb and other alkylenebis(dithi0carbamate) fungicides are degradedand metabolised via a common pathway. The primary degradationreaction of maneb in water, soils, plants and animals involves the initialdissociation of the metal complex and decomposition to numerousdegradation products including ethylenethiourea (ETU) and ethyleneurea(EU) as major products (Scheme 1). |
| storage | Color Code—Red: Flammability Hazard: Store in a flammable liquid storage area or approved cabinet away from ignition sources and corrosive and reactive materials. Prior to working with this chemical you should be trained on its proper handling and storage. Maneb must be stored to avoid contact with water, since violent reactions occur. Store in tightly closed containers in a cool, well-ventilated area away from acids, moisture, heat, and oxidizing materials. Where possible, automatically transfer material from drums or other storage containers to process containers. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHA Standard 1910.1045. |
| Shipping | UN2210 Maneb or Maneb preparations withnot <60% maneb, Hazard Class: 4.3; Labels: 4.3-Dangerouswhen wet material, 4.2-Spontaneously combustible material. UN2968 Maneb stabilized or Maneb preparations,stabilized against self-heating, Hazard Class: 4.3; Labels:4.3-Dangerous when wet material |
| Purification Methods | Crystallise this fungicide from EtOH. It is soluble in CHCl3. It is a skin irritant.[Beilstein 4 III 149, 4 IV 234.] |
| Degradation | Maneb (1) was rapidly hydrolysed in aqueous solutions (pH 5, 7 and 9)with DT50 values of <24 hours (PM). Dithiocarbamate compoundsdecompose in aqueous solutions following a common pathway thatinvolves the dissociation of the metal complex, and rapid rearrangementreactions to yield 5,6-dihydro-3H-imidazo[2,1-c]-1,2,4-dithiazole-3-thione(2) which is further degraded slowly to ETU (3). ETU in aqueous solutionwas ultimately converted into 2-imidazoline (4) and EU (5) (kaarsSijpesteijn and Vonk, 1974). |
| Incompatibilities | Incompatible with oxidizers (chlorates,nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause firesor explosions. Keep away from alkaline materials, strongbases, strong acids, oxoacids, epoxides, water.Dithiocarbamate esters are combustible. They react violently with powerful oxidizers such as calcium hypochlorite. Poisonous gases are generated by the thermaldecomposition of Dithiocarbamate compounds, includingcarbon disulfide, oxides of sulfur, oxides of nitrogen,hydrogen sulfide, ammonia, and methylamine. Thio anddithiocarbamates slowly decompose in aqueous solutionto form carbon disulfide and methylamine or otheramines. Such decompositions are accelerated by acids.Flammable gases are generated by the combination ofdithiocarbamate with aldehydes, nitrides, and hydrides.Dithiocarbamate are incompatible with acids, peroxides,and acid halides. |
| Waste Disposal | Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPAregulations governing storage, transportation, treatment,and waste disposal. Maneb is unstable to moisture and ishydrolyzed by acids and hot water. It decomposes at about100℃ but may spontaneously decompose vigorously whenstored in bulk. Incineration is the preferred disposalmeans. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following packagelabel directions or by contacting your local or federal environmental control agency, or by contacting your regionalEPA office |
Maneb Preparation Products And Raw materials
| Raw materials | Zinc chloride-->Ethylenediamine-->Mancozeb-->Zineb-->NABAM |
| Preparation Products | Mancozeb |
