Introduction：Basic information about Mangiferin CAS 4773-96-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Mangiferin Basic information
| Product Name: | Mangiferin |
| Synonyms: | 1,3,6,7-tetrahydroxy-2-[(3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one;1,3,6,7-TETRAHYDROXYXANTHONE-2-C-GLUCOSIDE;1,3,6,7-Tetrahydroxyxanthone C2-beta-D-glucoside;2-beta-d-glucopyranosyl-1,3,6,7-tetrahydroxy-9h-xanthen-9-one;mangiferin from mangifera indica leaves;MANGIFERIN 98% HPLC;Mangiferin90%;2-β-D-Glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one |
| CAS: | 4773-96-0 |
| MF: | C19H18O11 |
| MW: | 422.34 |
| EINECS: | 624-757-7 |
| Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;The group of Danshen;The group of Anemarrhenae;Xanthones;Inhibitors;standardized herbal extract;4773-96-0 |
| Mol File: | 4773-96-0.mol |
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Mangiferin Chemical Properties
| Melting point | 269-270°C |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly, Sonicated), Methanol (Slightly), Pyridine (Slightly, Heated) |
| pKa | 6.09±0.20(Predicted) |
| Boiling point | 842.7±65.0 °C(Predicted) |
| density | 1.843±0.06 g/cm3(Predicted) |
| form | Solid |
| color | Pale Yellow |
| Stability: | Hygroscopic |
| Major Application | food and beverages |
| Cosmetics Ingredients Functions | SKIN PROTECTING |
| InChI | 1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1 |
| InChIKey | AEDDIBAIWPIIBD-AZBPZEDSNA-N |
| SMILES | OC1=C([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C(O)=CC2OC3=CC(O)=C(O)C=C3C(=O)C1=2 |&1:3,4,5,7,9,r| |
| LogP | 0.130 (est) |
| CAS DataBase Reference | 4773-96-0(CAS DataBase Reference) |
Safety Information
| Hazard Codes | T+,Xi,Xn |
| Risk Statements | 28-36/37/38-22 |
| Safety Statements | 22-28-36/37-45-36-26-24/25 |
| RIDADR | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | OP1927800 |
| HS Code | 29389090 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 1 Oral |
Mangiferin Usage And Synthesis
| Description | Mangiferin is a plant natural polyphenol of C-glycosylxanthone structure and various pharmacological activities. It can be found in many plant species, among which the mango tree (Mangifera indica) is one of the primary sources. Mangiferin is also present in some medicinal herbs, influencing their therapeutic and preventive properties, and in honeybush (Cyclopia sp.), a popular South African herbal tea. Mangiferin dissolves well in water, so it can be easily extracted into infusions and decoctions. In the mangiferin molecule, four aromatic hydroxyl groups determine its strong antiradical and antioxidant properties. Mangiferin is also an efficient iron chelator, therefore preventing the generation of hydroxyl radicals in Fenton-type reactions[1]. |
| Chemical Properties | Yellow powder |
| Uses | MAO inhibitor, immunostimulant |
| Uses | Mangiferin is a xanthonoid, a chemical compound found in mangoes and in Anemarrhena asphodeloides rhizomes. Mangiferin has effect of hepatinica and choleretic, and is used to therapy hepatitis. Mangiferin is an anti-inflammatory, antivirotic, central nervous system inhibit function and immunologic suppression. Mangiferin has curative effect on chronic bronchitis. Mangiferin has cytotoxicity effect on hepatocellularcarcinoma ce1l, and may induce apoptosis. Mangiferin has the effect of antioxidation and delaying caducity. |
| Definition | ChEBI: A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position. |
| General Description | Mangiferin (MGF) is a natural bioactive polyphenol predominantly isolated from the Mangifera indica (Mango) tree. It has a xanthone glucoside structure. Mangiferin can also be found in other angiosperm plants and herbs. |
| Biochem/physiol Actions | Mangiferin has various pharmacological properties including antioxidant, anti-diabetic, anti-bacterial, cardioprotective, neuroprotective, and immunomodulatory activities. It has also displayed antidiabetic, antihyperlipidemic, and antiatherogenic properties in streptozotocin-induced diabetic rats. MGF exerts chemotherapeutic and chemo-preventative activities. It displays antioxidant, analgesic, and hepatoprotective activity against carbon tetrachloride-induced liver injury. MGF is a known accelerator of gastrointestinal transit (GIT). |
| References | [1] Adam Matkowski. “Mangiferin - a bioactive xanthonoid, not only from mango and not just antioxidant.” Mini reviews in medicinal chemistry 13 3 (2013): 439–55. |
Mangiferin Preparation Products And Raw materials
