Introduction：Basic information about Meclizine Dihydrochloride Monohydrate CAS 31884-77-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Meclizine Dihydrochloride Monohydrate Basic information
| Product Name: | Meclizine Dihydrochloride Monohydrate |
| Synonyms: | 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine hydrate dihydrochloride;Meclizine dihydrochloride monohydrate;1-[(4-Chlorophenyl)phenylMethyl]-4-[(3-Methylphenyl)Methyl]piperazine DiHydrochloride Hydrate;Meclizine Related CoMpound B;MECLIZINE HYDROCHLORIDE (500 MG);Meclizine hydrochloride;Antivert;Permesin |
| CAS: | 31884-77-2 |
| MF: | C25H27ClN2.2ClH.H2O |
| MW: | 481.892 |
| EINECS: | 688-525-7 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Heterocycles |
| Mol File: | 31884-77-2.mol |
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Meclizine Dihydrochloride Monohydrate Chemical Properties
| Melting point | 210-213°C |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White |
| Water Solubility | Insoluble in water. |
| Major Application | pharmaceutical (small molecule) |
| InChI | 1S/C25H27ClN2.2ClH.H2O/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;;/h2-13,18,25H,14-17,19H2,1H3;2*1H;1H2 |
| InChIKey | KDLHYOMCWBWLMM-UHFFFAOYSA-N |
| SMILES | [Cl-].[Cl-].Clc1ccc(cc1)C(N3CCN(CC3)Cc4cc(ccc4)C)c2ccccc2.O.[H+].[H+] |
| CAS DataBase Reference | 31884-77-2 |
Safety Information
| WGK Germany | WGK 3 |
| TSCA | Yes |
| HS Code | 2933599550 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
Meclizine Dihydrochloride Monohydrate Usage And Synthesis
| Chemical Properties | White Solid |
| Originator | Antivert,Roerig,US,1957 |
| Uses | Antiemetic and H1-histamine receptor antagonistMeclizine dihydrochloride monohydrate acts as an antiemetic. It is also used for the prevention and treatment of nausea during pregnancy. In addition to this, it is used in radiation sickness, vomiting or dizziness associated with motion sickness. Product purchased here is only for use in Research and Development. |
| Uses | Meclizine Dihydrochloride Monohydrate is used for the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness. |
| Definition | ChEBI: Meclizine hydrochloride is a diarylmethane. |
| Manufacturing Process | 32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. Thissolution is washed with a saturated solution of K2CO3 and dried on K2CO3. Thesolvent is evaporated and the residue is distilled under high vacuum. Theproduct of the condensation distills near 230°C at 2 mm Hg pressure and thecorresponding dihydrochloride melts at 217° to 224°C. |
| Brand name | Antivert (Pfizer). |
| Therapeutic Function | Antinauseant |
| General Description | Meclizine hydrochloride,1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazinedihydrochloride monohydrate (Bonine, Antivert), is atasteless, white or slightly yellowish crystalline powder that is practically insoluble in water (1:1,000). It differs fromchlorcyclizine in having an N-m-methylbenzyl group inplace of the N-methyl group. Although it is a moderately potentantihistaminic, meclizine is used primarily as an antinauseantin the prevention and treatment of motion sicknessand in the treatment of nausea and vomiting associated withvertigo. |
Meclizine Dihydrochloride Monohydrate Preparation Products And Raw materials
| Raw materials | Sodium amide-->Hydrogen-->3-Methylbenzyl chloride |
