Memogain CAS 224169-27-1

Introduction：Basic information about Memogain CAS 224169-27-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Memogain Basic information

• Product Name: Memogain
• Synonyms: Memogain;GLN-1062;6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, 6-benzoate, (4aS,6R,8aS)-;Galantamine benzoate D6Q: What is Galantamine benzoate D6 Q: What is the CAS Number of Galantamine benzoate D6;Galantamine benzoateQ: What is Galantamine benzoate Q: What is the CAS Number of Galantamine benzoate Q: What is the storage condition of Galantamine benzoate;Inhibitor,GLN-1062,GLN 1062,inhibit,GLN1062;(4aS,6R,8aS)-3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-yl benzoate;GLN-1062, 10 mM in DMSO
• CAS: 224169-27-1
• MF: C24H25NO4
• MW: 391.46
• Mol File: 224169-27-1.mol

Memogain Chemical Properties

• Boiling point: 523.2±50.0 °C(Predicted)
• density: 1.28±0.1 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: Soluble in DMSO
• pka: 7.78±0.40(Predicted)
• form: Solid
• color: White to yellow
• InChI: InChI=1S/C24H25NO4/c1-25-13-12-24-11-10-18(28-23(26)16-6-4-3-5-7-16)14-20(24)29-22-19(27-2)9-8-17(15-25)21(22)24/h3-11,18,20H,12-15H2,1-2H3/t18-,20-,24-/m0/s1
• InChIKey: JKVNJTYHRABHIY-WXVUKLJWSA-N
• SMILES: N1(C)CC2=CC=C(OC)C3O[C@]4([H])[C@@](C=C[C@H](OC(=O)C5=CC=CC=C5)C4)(C2=3)CC1

Memogain Usage And Synthesis

Uses

Galantamine Benzoate-D3 is an isotopic labelled compound of Galantamine Benzoate, a pro-drug that slows down plaque deposition and ameliorates behavior in 5X familial Alzheimer's disease mice.

in vivo

Benzgalantamine (Memogain, 0.3-3 mg/kg, intranasal, twice a day for 2 weeks) improves cognitive function by promoting neurogenesis in the hippocampus, specifically in the dentate gyrus and CA1 regions of the hippocampus in rats models^[2].

• Animal Model: Sprague Dawley rats models^[2]
• Dosage: 0.3-3 mg/kg
• Administration: intranasal, twice a day for 2 weeks
• Result: Increased the number of newly generated cells and immunolabeling of synaptic markers in the dentate gyrus and CA1 regions of the hippocampus.