Introduction：Basic information about Methanesulfonic anhydride CAS 7143-01-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Methanesulfonic anhydride Basic information
| Product Name: | Methanesulfonic anhydride |
| Synonyms: | fonic acid, 1,1'-anhydride;METHANESULPHONIC ANHYDRIDE;METHANESULFONIC ANHYDRIDE;METHYLSULFONIC ANHYDRIDE;Mesyl anhydride;Methanesulfonic acid, anhydride;methanesulfonicacid,anhydride;Mesic anhydride |
| CAS: | 7143-01-3 |
| MF: | C2H6O5S2 |
| MW: | 174.19 |
| EINECS: | 230-442-1 |
| Product Categories: | Organic Building Blocks;Sulfonic/Sulfinic Acid Anhydrides;Sulfur Compounds;bc0001 |
| Mol File: | 7143-01-3.mol |
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Methanesulfonic anhydride Chemical Properties
| Melting point | 64-67 °C (lit.) |
| Boiling point | 125 °C/4 mmHg (lit.) |
| density | 1,36 g/cm3 |
| vapor density | 3.3 (vs air) |
| refractive index | 1.5300 (estimate) |
| Fp | 125°C/4mm |
| storage temp. | Store at <= 20°C. |
| solubility | Soluble in organic solvents. |
| form | Powder, Crystals and/or Chunks |
| color | White to light brown to gray |
| Sensitive | Moisture Sensitive |
| BRN | 972316 |
| InChI | 1S/C2H6O5S2/c1-8(3,4)7-9(2,5)6/h1-2H3 |
| InChIKey | IZDROVVXIHRYMH-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)OS(C)(=O)=O |
| CAS DataBase Reference | 7143-01-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Methanesulfonic anhydride(7143-01-3) |
| EPA Substance Registry System | Methanesulfonic acid, anhydride (7143-01-3) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 14-35 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| F | 3-10 |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29041000 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Skin Corr. 1A |
Methanesulfonic anhydride Usage And Synthesis
| Chemical Properties | white to light brown to grey powder, crystals and/ |
| Uses | Methanesulfonic anhydride is used to prepare methylsulfonyl esters called as mesylates. It finds application in the reaction of aromatic alkylation. It reacts with dimethylsulfoxide to get sulfoxonium complex, which is a useful oxidizing agent. |
| Preparation | Methanesulfonic anhydride may be prepared by the dehydration of methanesulfonic acid with phosphorus pentoxide.
P2O5 + 6 CH3SO3H → 3 (CH3SO2)2O + 2 H3PO4
Methanesulfonic anhydride can be purified by distillation under vacuum (distillation of a solid) or by recrystallized from Methyl tert-butyl ether/toluene. |
| Safety | Not only is Methanesulfonic anhydride corrosive, posing potential risks to skin, eyes, and mucous membranes, but it is also sensitive to moisture. As a hygroscopic substance, exposure to water can lead to degradation, compromising its efficacy and safety. Therefore, meticulous storage conditions are paramount to ensure the stability of the compound. To safeguard the integrity of methanesulfonic anhydride, storing it in a cool and dry environment is recommended. The storage facility should be adequately ventilated to prevent the accumulation of vapors and maintain optimal conditions for the compound. Furthermore, the storage containers must be tightly sealed to prevent moisture ingress and subsequent degradation. |
Methanesulfonic anhydride Preparation Products And Raw materials
| Raw materials | Methanesulfonic acid-->asbestos |
| Preparation Products | 1-Boc-3-hydroxymethyl-piperazine-->4-Bromo-7-azaindole-->Dofetilide-->Cresol Red-->N-Phenylmethanesulfonamide-->Methyl 2-(MethylsulfonaMido)nicotinate-->Methanesulfonamide, N-(4-methoxyphenyl)- |
