Introduction：Basic information about Methoxypolyethylene glycols CAS 9004-74-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Methoxypolyethylene glycols Basic information
| Product Name: | Methoxypolyethylene glycols |
| Synonyms: | 2-ethanediyl),.alpha.-methyl-.omega.-hydroxy-Poly(oxy-1;ETHYLENE GLYCOL 750 MONOMETHYL ETHER POLYMER;ETHYLENE GLYCOL 5000 MONOMETHYL ETHER POLYMER;ETHYLENE GLYCOL 550 MONOMETHYL ETHER POLYMER;ETHYLENE GLYCOL 350 MONOMETHYL ETHER POLYMER;ETHYLENE GLYCOL 1900 MONOMETHYL ETHER POLYMER;METHOXY POLYETHYLENE GLYCOL 750;Methoxypolyethylene glycols |
| CAS: | 9004-74-4 |
| MF: | (C2H4O)nCH4O |
| MW: | 120.14698 |
| EINECS: | 618-394-3 |
| Product Categories: | PEG;Cosmetic;Cosmetic Ingredients & Chemicals;construction;Polydispersed PEG;Non-Ionic Detergents;Detergents;Detergents N to Z;Hydroxy;Materials Science;Monofunctional PEGs;Poly(ethylene glycol) and Poly(ethylene oxide);Polymer Science;Optimization Reagents;X-Ray Crystallography;Protein Structural Analysis;Proteomics;Polymers;bc0001 |
| Mol File: | 9004-74-4.mol |
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Methoxypolyethylene glycols Chemical Properties
| Melting point | 60-64 °C |
| Boiling point | >200°C/760mmHg |
| density | 1.094 g/mL at 25 °C |
| vapor density | >1 (vs air) |
| vapor pressure | 0.05 mm Hg ( 20 °C) |
| refractive index | n20/D 1.459 |
| Fp | 268 °C |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL at 25 °C, clear, colorless |
| form | semisolid |
| Specific Gravity | 1.094 |
| color | White to pale yellow |
| Odor | Mild odor |
| PH | 5.5-7.0 (25℃, 50mg/mL in H2O) |
| Water Solubility | Slightly miscible with water. |
| λmax | λ: 260 nm Amax: 0.06
λ: 280 nm Amax: 0.03 |
| Ω-end | hydroxyl |
| α-end | methoxy |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. |
| Cosmetics Ingredients Functions | HUMECTANT
SOLVENT |
| Cosmetic Ingredient Review (CIR) | Methoxypolyethylene glycols (9004-74-4) |
| InChI | 1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3 |
| InChIKey | XNWFRZJHXBZDAG-UHFFFAOYSA-N |
| SMILES | O(CCO)C |
| LogP | -0.800 (est) |
| EPA Substance Registry System | Poly(oxy-1,2-ethanediyl), .alpha.-methyl-.omega.-hydroxy- (9004-74-4) |
Safety Information
| Safety Statements | 24/25-22 |
| WGK Germany | 3 |
| RTECS | PE8271000 |
| F | 3 |
| TSCA | TSCA listed |
| HS Code | 29091990 |
| Storage Class | 11 - Combustible Solids |
Methoxypolyethylene glycols Usage And Synthesis
| Description | m-PEG36-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. |
| Chemical Properties | varies from viscous liquid to white flakes, depending |
| Uses | enteric coating controlled release and enteric release coatings |
| Uses | Methoxypolyethylene Glycol of with an average molecular mass of 350. Methoxypolyethylene Glycol (MPEG) is used in various applications such as micelles for drug delivery as well as in modifications of therapeutic proteins to improve their pharmacokinetics. |
| Uses | Methoxypolyethylene glycol 350 has been used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes. It has also been used in a study to investigate synthesis of a new amphiphilic poly(organophosphazene) by stepwise nucleophilic substitution. |
| Definition | ChEBI: A poly(ethylene glycol) terminated with a methyl group at one end. |
| Brand name | Carbowax Sentry Methoxypolyethylene Glycol (Union Carbide). |
| General Description | It is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether. Etherification of the PEG chain ends can be undertaken in basic conditions by reacting it with alkyl halides. mPEG can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator. |
| Solubility in organics | Acetone, chloroform, cyclohexanone, dichloromethane, DMF, MEK, toluene (hot), water |
| Toxics Screening Level | The initial threshold screening level (ITSL) for polyethylene glycol methyl ether , also known as dowanol TMH, is 13 μg/m3 based on an annual averaging time. |
Methoxypolyethylene glycols Preparation Products And Raw materials
| Preparation Products | Benzonatate |
