Methyl isothiocyanate CAS 556-61-6
Introduction：Basic information about Methyl isothiocyanate CAS 556-61-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Methyl isothiocyanate Basic information
| Product Name: | Methyl isothiocyanate |
| Synonyms: | vorlex201(nor-am);Vortex;WN 12;wn12;METHYL ISOTHIOCYANATE FOR PROTEIN&;METHYL-ISO-THIOCYANATE PESTANAL, 250 MG;Methyl #niso-thiocyanate;Methylisothiocyanate,98% |
| CAS: | 556-61-6 |
| MF: | C2H3NS |
| MW: | 73.12 |
| EINECS: | 209-132-5 |
| Product Categories: | Isothiocyanates;Organic Building Blocks;Sulfur Compounds;Thiocyanates/Isothiocyanates;Alpha sort;Fungicides;Herbicides;H-MAlphabetic;M;META - METHPesticides&Metabolites;NematicidesPesticides;Others;OthersPesticides&Metabolites;Pesticides;Pesticides&Metabolites;Organics |
| Mol File: | 556-61-6.mol |
Methyl isothiocyanate Chemical Properties
| Melting point | 30-34 °C(lit.) |
| Boiling point | 117-118 °C(lit.) |
| density | 1.069 g/mL at 25 °C(lit.) |
| vapor pressure | 21 mm Hg ( 20 °C) |
| refractive index | nD37 1.5258 |
| FEMA | 4426 | METHYL ISOTHIOCYANATE |
| Fp | 90 °F |
| storage temp. | 2-8°C |
| solubility | H2O: slightly soluble |
| form | Low Melting Solid |
| color | White to pale yellow |
| Odor | at 0.01 % in propylene glycol. pungent mustard horseradish |
| Odor Type | pungent |
| biological source | rabbit |
| Water Solubility | 7.6 g/L |
| Sensitive | Moisture Sensitive |
| Merck | 14,6092 |
| JECFA Number | 1884 |
| Specific Activity | 19-25nmol/min·mg |
| BRN | 605319 |
| Stability: | Stable. Incompatible with strong oxidizing agents, alcohols, strong bases, amines. |
| InChIKey | LGDSHSYDSCRFAB-UHFFFAOYSA-N |
| LogP | 1.3 at 20℃ |
| CAS DataBase Reference | 556-61-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Methane, isothiocyanato-(556-61-6) |
| EPA Substance Registry System | Methyl isothiocyanate (556-61-6) |
Safety Information
| Hazard Codes | T,N |
| Risk Statements | 23/25-34-43-50/53 |
| Safety Statements | 36/37-38-45-60-61 |
| RIDADR | UN 2477 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | PA9625000 |
| F | 21 |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | I |
| HS Code | 29309090 |
| Storage Class | 10 - Combustible liquids |
| Hazardous Substances Data | 556-61-6(Hazardous Substances Data) |
| Toxicity | LD50 in rats, mice (mg/kg): 220, 110 orally; in rabbits (mg/kg): 33 dermally (Vernot); LD50 s.c. in mice: 0.05 g/kg (Klesse, Lukoschek) |
| Description | Methyl iso thio cyanate is the organo sulfur compound with the formula CH3N = C = S . This low melting colorless solid is a powerful lachrymator. As a precursor to a variety of valuable bioactive compounds, it is the most important organic iso thio cyanate in industry. |
| Chemical Properties | Colorless to tan liquid; pungent, penetrating, mustard-like odor. |
| Chemical Properties | colourless solid |
| Chemical Properties | Methyl isothiocyanate is a crystalline solid.Horseradish, acrid odor. |
| Occurrence | Reported found in horseradish. |
| Uses | Pesticide; soil fumigant. |
| Uses | Usually used to study the effect of pesticide Metam (methyl isothiocyanate is its active ingredient) in the streamside microbial communities of the upper Sacramento river |
| Uses | Pesticide and soil fumigant used to control insects, soil fungi, nematodes. |
| Application | Solutions of MITC are used in agriculture as soil fumigants, mainly for protection against fungi and nematodes. MITC is a building block for the synthesis of 1,3,4 - thiadiazoles, which are heterocyclic compounds used as herbicides. Commercial products include "Spike", "Ustilan," and "Erbotan." Well known pharmaceuticals prepared using MITC include Zantac and Tagamet. |
| Definition | ChEBI: An isothiocyanate having a methyl group attached to the nitrogen. |
| Reactions | A characteristic reaction is with amines to give methyl thioureas: CH3NCS + R2NH → R2NC(S)NHCH3 Other nucleophiles add similarly. |
| Aroma threshold values | Very high strength odor; recommend smelling in a 0.01% solution or less |
| General Description | A colorless liquid with a sharp odor. Lethal by inhalation of even small quantities of vapor. Does not have odor warning characteristics at low concentrations. Do not rely on the sense of smell to warn about the presence of vapors. Denser than water. Flash point below 20°F. May cause tearing and irritate the eyes, skin, nose and throat. |
| Air & Water Reactions | Highly flammable. Methyl isothiocyanate reacts with water to form carbon dioxide and methylamine gases. |
| Reactivity Profile | Isocyanates and thioisocyanates, such as Methyl isothiocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol. |
| Hazard | Toxic by ingestion, strong irritant to eyesand skin. |
| Health Hazard | Very toxic; probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 lb.) person. Highly irritating to skin, mucous membrances, and eyes. Human oral minimum lethal dose: approximately 1 g/kg. |
| Fire Hazard | (Non-Specific -- Pesticide, Solid, n.o.s.) Methyl isothiocyanate may burn, but does not ignite readily. Fire may produce irritating or poisonous gases. When heated Methyl isothiocyanate emits very dangerous cyanides and sulfur compounds. Do not store below -4F or at elevated temperatures. Keep away from sparks. |
| Flammability and Explosibility | Non flammable |
| Safety | MITC is a dangerous lachrymator as well as being poisonous. |
| Synthesis | It is prepared industrially by two routes. Annual production in 1993 was estimated to be 4M kg. The main method involves the thermal rearrangement of methyl thio cyanate : CH3S - C ≡ N → CH3N = C = S It is also prepared via with the reaction of methylamine with carbon disulfide followed by oxidation of the resulting dithio carbamate with hydrogen peroxide. A related method is useful to prepare this compound in the laboratory. MITC forms naturally upon the enzymatic degradation of gluco capparin , a modified sugar found in capers. |
| Potential Exposure | It is used as a soil fumigant. A mixture of methyl isothiocyanate and chlorinated C-3 hydrocarbons is used as a soil fumigant for control of weeds, fungi,insects, and nematodes. |
| First aid | If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at leastFirst Aid: If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifing upper and lower lids. Seek med-ical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, includ-ing resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medi-cal attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.Medical observation is recommended for 24- -48 h afterbreathing overexposure, as pulmonary edema may bedelayed. As first aid for pulmonary edema, a doctor orauthorized paramedic may consider administering a cortico-steroid spray. |
| Environmental Fate | Soil. Though no products were reported, the reported half-life in soil is <14 days(Worthing and Hance, 1991). Chemical/Physical. Emits toxic fumes of nitrogen and sulfur oxides when heated todecomposition (Sax and Lewis, 1987). |
| Metabolic pathway | Methyl isothiocyanate is slowly decomposed in pure water, formingmethylamine. It is metabolised in rats to the mercapturate via the glutathioneconjugate which serves as a potential source of methyl isothiocyanate.Methyl isothiocyanate is reactive with cellular thiols and aminesand its toxicity is associated with these reactions. |
| storage | (1) Color Code—Red: Flammability Hazard: Storein a flammable liquid storage area or approved cabinetaway from ignition sources and corrosive and reactivematerials. (2) Color Code—Blue: Health Hazard/Poison:Store in a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area. Sources of ignition, such as smoking andopen flames, are prohibited where methyl isothiocyanate isused, handled, or stored in a manner that could create apotential fire or explosion hazard. Metal containers involving the transfer of 5 gallons or more of this chemical shouldbe grounded and bonded. Drums must be equipped withself-closing valves, pressure vacuum bungs, and flamearresters. Use only nonsparking tools and equipment, especially when opening and closing containers of this chemical. Wherever this chemical is used, handled, manufactured,or stored, use explosion-proof electrical equipment andfittings. |
| Shipping | UN2477 Methyl isothiocyanate, Hazard class:6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammableliquid, Inhalation Hazard Zone B. |
| Degradation | Methyl isothiocyanate is unstable and reactive. It is rapidly hydrolysed byalkalis but more slowly in acidic or neutral solutions. DT50 values forhydrolysis were 85,490 and 110 hours at pH 5,7 and 9, respectively. It issensitive to oxgen and to light (PM). The relatively slow hydrolysis ofmethyl isothiocyanate in pure water can be accelerated by adding highconcentrations of acid. Thiocarbamic acid is formed that in turndecomposes rapidly to protonated methylamine. Addition of water to theisothiocyanate N=C bond via a mechanism involving synchronous nucleophilicattack at carbon and proton transfer to nitrogen with a cyclic transitionstate is proposed. Methyl isothiocyanate is 107 times less susceptibleto acid catalysis in water than its O-analogue (Joseph et al., 1992). It willalso combine with various essential nucleophilic centres in biologicalsystems. For example, it reacts with cysteine in vitro, forming a dithiocarbamatederivative in solutions of pH greater than 6 (Goksoyr, 1964). The fungicide is photolysed in the gas phase with a half life of 10 hoursunder irradiation from a xenon arc lamp and slightly more than one dayfor late summer sunlight in Nevada, USA. The relatively rapid photolysisof methyl isothiocyanate had not previously been observed in otherexperiments in aqueous solutions where rates were 20 times slower.Products of photolysis were methyl isocyanide (2), sulfur dioxide, hydrogensulfide, N-methylformamide (3), methylamine and carbonyl sulfide.Methyl isocyanide (2) was initially the main product and it yieldedmethyl isocyanate (4) (Geddes et al., 1995). |
| Toxicity evaluation | MITC stimulates chemesthesis, the activation of receptorsassociated with sensations of pain, touch, or thermal perception,through activation of transient receptor potential (TRPA1)ion channels. Isothiocyanate molecules have an electrophiliccarbon atom that reacts with nucleophilic components, such ascysteine residues in the TRPA1 channels that are highly sensitiveand serve as a warning mechanism to prevent tissuedamage. MITC can form a reversible covalent bond withreceptors to stimulate a reaction instead of acting directlythrough tissue damage. MITC is less potent than other isothiocyanates,such as allyl isothiocyanate (i.e., the activecomponent of horseradish, wasabi, and mustard). At lowconcentrations, endogenous nucleophiles (e.g., GSH) mayneutralize the electrophilic carbon and, therefore, preventdamage, but as concentrations increase their effectivenessdecreases. Although the mode of action of MITC for systemictoxicity is not known, MITC is proposed to react with, andinactivate, the sulfhydryl group of essential enzymes in livingorganisms. |
| Incompatibilities | Dust may form explosive mixture withair. Reacts with water, releasing carbon dioxide andmethylamine gases. Unstable and reactive; sensitive to oxygen and to light. Incompatible with oxidizers (chlorates,nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,strong acids, oxoacids, epoxides, alcohols, strong bases,amines, water, heat and cold. Attacks iron, zinc and othermetals |
| Waste Disposal | In accordance with 40CFR165 recommendations for the disposal of pesticides andpesticide containers. Must be disposed properly by following package label directions or by contacting your local orfederal environmental control agency, or by contactingyour regional EPA office |
Methyl isothiocyanate Preparation Products And Raw materials
| Raw materials | Methylamine-->Carbon disulfide-->Ethyl chloroformate-->ISOTHIOCYANATE, POLYMER-BOUND, 200-400 |
| Preparation Products | N-METHYLTHIOUREA-->Methimazole-->4-METHYL-5-PYRIDIN-4-YL-4H-[1,2,4]TRIAZOLE-3-THIOL-->1-Methyl-3-phenyl-2-thiourea-->3H-1,2,4-Triazole-3-thione, 2,4-dihydro-5-(hydroxymethyl)-4-methyl- (9CI)-->4-METHYL-1-(TRIFLUOROACETYL)-3-THIOSEMICARBAZIDE-->N-methylthiatriazol-5-amine-->N-(2-BROMOPHENYL)-N'-METHYLTHIOUREA-->AKOS USSH-4110876-->1H-Pyrrolo[1,2-c]imidazol-1-one,hexahydro-2-methyl-3-thioxo-(9CI) |
