Methyl methanesulfonate CAS 66-27-3
Introduction：Basic information about Methyl methanesulfonate CAS 66-27-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Methyl methanesulfonate Basic information
| Product Name: | Methyl methanesulfonate |
| Synonyms: | MMS;METHYL METHANESULPHONATE;METHYL METHANESULFONATE;METHANESULFONIC ACID METHYL ESTER;as-Dimethyl sulphite;as-dimethylsulfite;as-dimethylsulphite;CB 1540 |
| CAS: | 66-27-3 |
| MF: | C2H6O3S |
| MW: | 110.13 |
| EINECS: | 200-625-0 |
| Product Categories: | |
| Mol File: | 66-27-3.mol |
Methyl methanesulfonate Chemical Properties
| Melting point | 20°C |
| Boiling point | 202-203 °C(lit.) |
| density | 1.3 g/mL at 25 °C(lit.) |
| vapor pressure | 0.8 hPa (59 °C) |
| refractive index | n |
| Fp | 220 °F |
| storage temp. | Store below +30°C. |
| solubility | 200g/l |
| form | Liquid |
| color | Colorless to pale yellow |
| Water Solubility | 200 g/L (20 ºC) |
| Merck | 14,6097 |
| BRN | 1098586 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. |
| InChI | 1S/C2H6O3S/c1-5-6(2,3)4/h1-2H3 |
| InChIKey | MBABOKRGFJTBAE-UHFFFAOYSA-N |
| SMILES | COS(C)(=O)=O |
| CAS DataBase Reference | 66-27-3(CAS DataBase Reference) |
| IARC | 2A (Vol. 7, Sup 7, 71) 1999 |
| NIST Chemistry Reference | Methanesulfonic acid, methyl ester(66-27-3) |
| EPA Substance Registry System | Methyl methanesulfonate (66-27-3) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 45-22-36/37/38-68 |
| Safety Statements | 53-26-45-36/37/39 |
| RIDADR | UN 2810 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | PB2625000 |
| F | 21 |
| TSCA | TSCA listed |
| HS Code | 2905 19 00 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 2 Carc. 2 Eye Irrit. 2 Muta. 1B Repr. 2 Skin Irrit. 2 Skin Sens. 1 STOT RE 2 Inhalation |
| Hazardous Substances Data | 66-27-3(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 225 mg/kg |
| Chemical Properties | colourless liquid |
| Chemical Properties | Clear, colorless to amber liquid. |
| Uses | Methyl methanesulfonate is a DNA adduct that adds methyl groups to Dan at 7-guanine, 3-guanine and 3-adenine. |
| Uses | Experimentally as mutagen, teratogen, brain carcinogen. |
| Definition | ChEBI: A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol. |
| General Description | Colorless to amber liquid. |
| Air & Water Reactions | Water soluble. |
| Reactivity Profile | Methyl methanesulfonate is incompatible with strong oxidizing agents, strong acids and strong bases. |
| Fire Hazard | Methyl methanesulfonate is combustible. |
| Safety Profile | Confirmed carcinogenwith carcinogenic and neoplastigenic data.Poison by ingestion, intraperitoneal,intravenous, and subcutaneous routes.Human mutation data reported.Experimental teratogenic and reproductiveeffects. When heated to decomposition itemits toxic fumes of SOx. |
| Potential Exposure | Research chemical and cancer drug.No longer produced commercially in the United States. |
| Carcinogenicity | Methyl methanesulfonate is reascarcinogen based on sufficient evionably anticipated to be a human dence of carcinogenicity from studies in experimental animals. |
| Shipping | UN2810 Toxic liquids, organic, n.o.s., HazardClass: 6.1; Labels: 6.1-Poisonous materials, TechnicalName Required. |
| Purification Methods | Purify the ester by careful fractionation and collecting the middle fraction. Suspected CARCINOGEN. Note that MeSO3H has b 167-167.5o/10mm and methanesulfonic anhydride has b 138o/10mm)—both are possible impurities. [Beilstein 4 IV 11.] |
| Incompatibilities | Incompatible with oxidizers (chlorates,nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,strong acids, oxoacids, epoxides. Esters are generallyincompatible with nitrates. Moisture may cause hydrolysisor other forms of decomposition |
| Waste Disposal | It is inappropriate and possibly dangerous to the environment to dispose of lab chemicals or expired or waste drugs and pharmaceuticals byflushing them down the toilet or discarding them to thetrash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffeegrounds, double-bagged in plastic, discard in trash.Larger quantities shall carefully take into considerationapplicable DEA, EPA, and FDA regulations. If possiblereturn the pharmaceutical to the manufacturer for properdisposal being careful to properly label and securelypackage the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transportedby a state licensed medical waste contractor to dispose byburial in a licensed hazardous or toxic waste landfill orincinerator. |
Methyl methanesulfonate Preparation Products And Raw materials
| Raw materials | Methanol-->Dichloromethane-->Triethylamine-->Methanesulfonyl chloride-->Trimethoxymethane |
| Preparation Products | O6-METHYL-2'-DEOXYGUANOSINE |
