Micafungin sodium CAS 208538-73-2

Introduction：Basic information about Micafungin sodium CAS 208538-73-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Micafungin sodium Basic information

• Product Name: Micafungin sodium
• Synonyms: Micafungin sodium;1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneuMocandin A0 MonosodiuM Salt;Funguard;Micafungin SodiuM(FK-463, MycaMine);Mycamine;CS-705;FK 463; FUNGUARD; MYCAMINE;micafungin sodium Impurity
• CAS: 208538-73-2
• MF: C56H72N9NaO23S
• MW: 1294.28
• EINECS: 810-840-7
• Product Categories: Inhibitors;API
• Mol File: 208538-73-2.mol

Micafungin sodium Chemical Properties

• Melting point: >180°C (dec.)
• storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
• form: Solid
• color: White to Off-White
• Stability: Hygroscopic
• InChIKey: OEGCPTZZFOGTHP-BHSLVOOXNA-N
• CAS DataBase Reference: 208538-73-2

Micafungin sodium Usage And Synthesis

Description

The semi-synthetic echinocandin antifungal agent,micafungin sodium (15), is a 1,3-β-glucan synthase inhibitordiscovered by Fujisawa. It is for the treatment andprevention of infections caused by Aspergillus and Candidasuch as fungemia, respiratory mycosis and gastrointestinalmycosis.

Chemical Properties

Off-White Solid

Uses

An echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall, and represent a valuable treatment option for fungal infections.

Uses

Micafungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthesis. It has fungicidal activity against virtually all species of Candida, including those resistant to fluconazole, and is fungistatic against Aspergillus spp.[Cayman Chemical]

Uses

Micafungin sodium is the salt of the semi-synthetic cyclic lipopeptide, micafungin, a member of the echinocandin class that was reported in 1999 from Fujisawa in Japan. The sodium salt takes advantage of the aryl sulphate moiety providing improved water solubility and is the preferred salt for pharmaceutical applications. Like all echinocandins, micafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.

Definition

ChEBI: Micafungin sodium is an organic sodium salt and an antibiotic antifungal drug.

Brand name

Mycamine(Astellas).

Synthesis

The key intermediate for the side chain ofmicafungin (15) was prepared by regioselective 1,3-dipolarcycloaddition reaction of 4-methoxycarbonylbenzhydroxamicacid chloride (147) and 4-pentyloxyphenylacetylene (148)with TEA in THF. Basic hydrolysis of thus obtainedester 149 , followed by condensation with 1-hydroxybenzotriazole (HOBT) gave the corresponding activated ester 150 in 95% yield. The cyclic peptide core151, obtained by acylase-catalyzed hydrolysis of the naturalproduct FR901379, was acylated with 150 to givemicafungin (15) in 53% yield.