Microcrystalline cellulose CAS 9004-34-6
Introduction：Basic information about Microcrystalline cellulose CAS 9004-34-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Microcrystalline cellulose Basic information
| Product Name: | Microcrystalline cellulose |
| Synonyms: | AVICEL PH;AVICEL PH 101(R);AVICEL PH 102;AVICEL PH 105(R);AVICEL(R);''AVICEL(R)'';AVICEL SF;AVIRIN |
| CAS: | 9004-34-6 |
| MF: | (C12H20O10)n |
| MW: | 324.28 |
| EINECS: | 232-674-9 |
| Product Categories: | CarbohydrateSerum-free Media;Companion Products and Reagents;Insect Platform;Metabolic Pathways;Metabolites and Cofactors on the Metabolic Pathways Chart;Nutritional Supplements;Carbohydrate;API;Cellulose;Materials Science;Natural Polymers;Polymer Science;Polymers;9004-34-6 |
| Mol File: | 9004-34-6.mol |
Microcrystalline cellulose Chemical Properties
| Melting point | 76-78 °C(Solv: acetone (67-64-1); chloroform (67-66-3)) |
| bulk density | 70-400kg/m3 |
| density | 1.5 g/cm3 (20℃) |
| refractive index | n20/D 1.504 |
| Fp | 164 °C |
| storage temp. | room temp |
| solubility | Practically insoluble in water, in acetone, in anhydrous ethanol, in toluene, in dilute acids and in a 50 g/L solution of sodium hydroxide |
| form | powder |
| color | White or almost white |
| Odor | Odorless |
| PH | 5-7.5 (100g/l, H2O, 20℃)(slurry) |
| Optical Rotation | -120 (Cuprammonium hydroxide solution) |
| biological source | spruce |
| Water Solubility | insoluble |
| Merck | 14,1965 |
| Exposure limits | ACGIH: TWA 10 mg/m3 OSHA: TWA 15 mg/m3; TWA 5 mg/m3 NIOSH: TWA 10 mg/m3; TWA 5 mg/m3; TWA 1 mg/m3 |
| Dielectric constant | 3.2（Ambient） |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Cosmetics Ingredients Functions | OPACIFYING LIGHT STABILIZER ABSORBENT BULKING EMULSION STABILISING ABRASIVE ANTICAKING VISCOSITY CONTROLLING |
| Cosmetic Ingredient Review (CIR) | Microcrystalline cellulose (9004-34-6) |
| InChI | 1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3?,4?,5?,6?,7?,8?,9?,10-,11?,12+/m1/s1 |
| InChIKey | UFHFLCQGNIYNRP-UHFFFAOYSA-N |
| SMILES | O1[C@H](C(C(C(C1CO)O)O)O)O[C@@H]2C(OC(C(C2O)O)O)CO |
| EPA Substance Registry System | Cellulose (9004-34-6) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 37 |
| Safety Statements | 24/25 |
| OEB | B |
| OEL | TWA: 10 mg/m3 (total) |
| WGK Germany | 3 |
| RTECS | FJ5950200 |
| F | 3 |
| Autoignition Temperature | 232 °C |
| TSCA | TSCA listed |
| HS Code | 39129090 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
| Chemical Properties | Microcrystalline cellulose and carboxymethylcellulose sodiumoccurs as a white or off-white odorless and tasteless hygroscopicpowder containing 5–22% sodium carboxymethylcellulose. It is awater-dispersible organic hydrocolloid. |
| Chemical Properties | Microcrystalline cellulose is a purified, partially depolymerizedcellulose that occurs as a white, odorless, tasteless, crystallinepowder composed of porous particles. It is commercially availablein different particle sizes and moisture grades that have differentproperties and applications. |
| Occurrence | The fiber in typical paper can be called “cellulosic”, meaning that cellulose is its most prominent component. Cellulose is present not only in wood, but also in various non-woody plants, such as straw, sugarcane (bagasse), reeds, and hemp. |
| Uses | High purity cellulose powders for partition chromatography. |
| Uses | ACCEL-101 is most widely used for direct compression tableting and wet granulation.ACCEL-102 has similar compression properties to ACCEL-101. However, it has larger particle size and therefore, may be of value in improving the flow if fine powders.ACCEL |
| Uses | cellulose is a thickener and an emulsifier. It is obtained from plants. cellulose (microcrystalline) is used as an emulsifier in cosmetic creams. It is the chief constituent of plant fiber. |
| Uses | Wood contains 50–70% cellulose; cotton and other textile fibers of plant origin contain 65–95%; rayon is prepared by dissolving natural cellulose and then precipitating it from solution, with some loss of crystallinity. Cellulose is made into cellophane film and is used to form fibers, resins, coatings and gums. |
| Uses | Cellulose is a carbohydrate polymer made up of glucose units. It consists of fibrous particles and is used as a fiber source and bulking agent in low-calorie formulations. |
| Uses | Microcrystalline Cellulose is a gum that is the nonfibrous form of cellulose, an alpha-cellulose. It is dispersible in water but not soluble, requiring considerable energy to disperse and hydrate. In this form it is used in dry applications such as tableting, capsules, and shredded cheese where it functions as a non-nutritive filler, binder, flow aid, and anticaking agent. By the addition of carboxymethylcellulose to the alpha-cellulose prior to drying, improved functional properties of hydration and dispersion are obtained. This product is designed for use in water dispersions, being insoluble in water but dispersing in water to form colloidal sols below 1% and white opaque gels above the 1% usage level. It is used as a heat shock stabilizer and bodying agent in frozen desserts, as an opacifier in low-fat dressings, as a foam stabilizer in whipped toppings, and as an emulsifier in dressings. Also termed cellulose gel. |
| Definition | A natural carbohydrate high polymer (polysaccha-ride) consisting of anhydroglucose units joined byan oxygen linkage to form long molecular chainsthat are essentially linear. It can be hydrolyzed toglucose. The degree of polymerization is from 1000for wood pulp to 3500 for cotton fiber, giving amolecular weight from 160,000 to 560,000.Cellulose is a colorless solid, d approximately 1.50,insoluble in water and organic solvents. It willswell in sodium hydroxide solution and is solublein Schweitzer’s reagent. It is the fundamental con-stituent of all vegetable tissues (wood, grass, cotton,etc.) and the most abundant organic material in theworld. Cotton fibers are almost pure cellulose; woodcontains approximately 50%.The physical structure of cellulose is unusual in that itis not a single crystal but consists of crystalline areasembedded in amorphous areas. Chemical reagentspenetrate the latter more easily than the former. Cel-lulose is virtually odorless and tasteless and is com-bustible, with an ignition point of approximately450F. In some forms, it is flammable. For example,railroad shipping regulations require a flammablelabel on such items as burnt fiber, burnt cotton,wet waste paper, and wet textiles. Fires have beenknown to occur in warehouses in which telephonebooks were stored. These were undoubtedly due to heat buildup in the paper caused by microbialactivity and self-sustaining oxidation. |
| Production Methods | Microcrystalline cellulose and carboxymethylcellulose sodium is aspray- or bulk-dried blend of microcrystalline cellulose and sodiumcarboxymethylcellulose. It is prepared by the chemical depolymerizationof highly purified wood pulp. The original crystalline areasof the pulp fibers are combined with sodium carboxymethylcellulose,which serves as a protective colloid and also facilitatesdispersion of the product; it is then either spray- or bulk-dried. |
| Production Methods | Microcrystalline cellulose is manufactured by controlled hydrolysiswith dilute mineral acid solutions of α-cellulose, obtained as a pulpfrom fibrous plant materials. Following hydrolysis, the hydrocelluloseis purified by filtration and the aqueous slurry is spraydriedto form dry, porous particles of a broad size distribution. |
| General Description | Odorless, white powdery fibers. Density 1.5 g cm-3. The biopolymer composing the cell wall of vegetable tissues. Prepared by treating cotton with an organic solvent to de-wax Cellulose microcrystalline and removing pectic acids by extration with a solution of sodium hydroxide. The principal fiber composing the cell wall of vegetable tissues (wood, cotton, flax, grass, etc.). Technical uses depend on the strength and flexibility of its fibers. Insoluble in water. Soluble with chemical degradation in sulfuric aicd, and in concentrated solutions of zinc chloride. Soluble in aqueous solutions of cupric ammonium hydroxide (Cu(NH3)4(OH)2). |
| Reactivity Profile | Cellulose microcrystalline is combustible. Incompatible with strong oxidizing agents including bromine pentafluoride, sodium nitrate, fluorine, perchlorates, perchloric acid, sodium chlorate, magnesium perchlorate, F2, zinc permanganate, sodium nitrite, sodium nitrate, sodium peroxide. Nitration with a mixture of nitric and sulfuric acids produces Cellulose microcrystalline nitrates (celluloid pyroxylin, soluble pyroxyline, guncotton) which are flammable or explosive. |
| Health Hazard | Cellulose is inert and is classifiedas a nuisance dust. It has little, if any, adverse effect on thelung, and there are no reports of organicdisease or toxic effect. The health effectsattributed to wood, cotton, flax, jute, and hempare not attributable to their cellulose contentbut rather to the presence of other substances. Cellulose fibers were found in the bloodand urine of human volunteers fed dyed cellulose;there were no ill effects. |
| Pharmaceutical Applications | Microcrystalline cellulose and carboxymethylcellulose sodium isused to produce thixotropic gels suitable as suspending vehicles inpharmaceutical and cosmetic formulations. The sodium carboxymethylcelluloseaids dispersion and serves as a protective colloid. Concentrations of less than 1% solids produce fluid dispersions,while concentrations of more than 1.2% solids produce thixotropicgels. When properly dispersed, it imparts emulsion stability, opacityand suspension in a variety of products, and is used in nasal sprays,topical sprays and lotions, oral suspensions, emulsions, creamsand gels. |
| Industrial uses | Cellulose is the main constituent of the structureof plants (natural polymer) that, whenextracted, is employed for making paper,plastics, and in many combinations. Celluloseis made up of long-chain molecules inwhich the complex unit C6H10O5 is repeatedas many as 2000 times. It consists of glucose molecules with three hydroxyl groups foreach glucose unit. One of the simplest forms of cellulose usedindustrially is regenerated cellulose, in whichthe chemical composition of the finished productis similar to that of the original cellulose. Itis made from wood or cotton pulp digested ina caustic solution. Cellophane is a regeneratedcellulose in thin sheets for wrapping and otherspecial uses include windings on wire andcable. |
| Biochem/physiol Actions | Cellulose helps in maintaining the structural stability of plant cell walls. It is an important component of paper and fabrics made from cotton, and linen. |
| Safety Profile | A nuisance dust. When heated to decomposition it emits acrid smoke and irritating fumes. |
| Safety | Microcrystalline cellulose is widely used in oral pharmaceuticalformulations and food products and is generally regarded as arelatively nontoxic and nonirritant material. Microcrystalline cellulose is not absorbed systemically followingoral administration and thus has little toxic potential. Consumptionof large quantities of cellulose may have a laxative effect, althoughthis is unlikely to be a problem when cellulose is used as an excipientin pharmaceutical formulations. Deliberate abuse of formulations containing cellulose, either byinhalation or by injection, has resulted in the formation of cellulosegranulomas. |
| storage | Microcrystalline cellulose and carboxymethylcellulose sodium ishygroscopic and should not be exposed to moisture. It is stable overa pH range of 3.5–11. Store in a cool, dry place. Avoid exposure toexcessive heat. |
| Incompatibilities | Microcrystalline cellulose is incompatible with strong oxidizingagents. |
| Regulatory Status | Microcrystalline cellulose and carboxymethylcellulose sodium is a mixture of two materials both of which are generally regarded as nontoxic: Microcrystalline cellulose GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; oral capsules, powders, suspensions, syrups, and tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Carboxymethylcellulose sodium GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; intra-articular, intrabursal, intradermal, intralesional, and intrasynovial injections; oral drops, solutions, suspensions, syrups and tablets; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients. |
Microcrystalline cellulose Preparation Products And Raw materials
| Raw materials | Sucrose-->Defatted cotton-->COTTONSEED OIL-->Lignin |
| Preparation Products | Potassium chloride-->Polyinosinic acid-polycytidylic acid-->Sodium carboxymethyl cellulose-->naphtha steam reforming catalysts-->Hydroxypropyl methyl cellulose-->D(+)-Xylose-->Tirofiban-->Ethyl cellulose-->Lignin-->TAMARIND GUM-->biodegrddable finishing agent for fabric-->Dispersant CS |
