Introduction：Basic information about Mitiglinide calcium dihydrate CAS 207844-01-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Mitiglinide calcium dihydrate Basic information
| Product Name: | Mitiglinide calcium dihydrate |
| Synonyms: | (aS,3aR,7aS)-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid calcium salt dihydrate;(S)-2-Benzyl-4-oxo-4-(cis-perhydroisoindol-2-yl)butyric acid calcium salt dihydrate;Mitiglinide calcium;3006 MITIGLINIDE CALCIUM HYDRATE;2H-ISOINDOLE-2-BUTANOICACID,OCTAHYDRO-G-OXO-A-(PHENYLMETHYL)-,CALCIUMSALT,DIHYDRATE;Mitiglinide CalciuM dihydrate;(S)-2-Benzyl-4-oxo-4-(cis-perhydroisoindol-2-yl)butyric Acid Calcium Salt Hydrate;KAD-1229 Calcium Hydrate |
| CAS: | 207844-01-7 |
| MF: | C38H52CaN2O8 |
| MW: | 704.91 |
| EINECS: | 1308068-626-2 |
| Product Categories: | APIs;Antidiabetic;Intermediates & Fine Chemicals;Pharmaceuticals;API;Diabetes Research;Chiral Reagents |
| Mol File: | 207844-01-7.mol |
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Mitiglinide calcium dihydrate Chemical Properties
| Melting point | 179-185°C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Slightly) |
| form | Solid |
| color | White |
| InChIKey | QEVLNUAVAONTEW-HNIWBTCONA-L |
| SMILES | N1(C[C@]2([H])CCCC[C@]2([H])C1)C(=O)C[C@H](CC1=CC=CC=C1)C(=O)O[Ca]OC(=O)[C@@H](CC1=CC=CC=C1)CC(=O)N1C[C@@]2([H])CCCC[C@@]2([H])C1.O.O |&1:2,8,14,29,42,48,r| |
| CAS DataBase Reference | 207844-01-7(CAS DataBase Reference) |
Safety Information
Mitiglinide calcium dihydrate Usage And Synthesis
| Description | Mitiglinide calcium hydrate (KAD-1229) is an insulinotropic agent. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels. |
| Chemical Properties | White Solid |
| Uses | KAD-1229 Calcium Hydrate (Mitiglinide calcium dihydrate) could binds to sulfonylurea receptors and inhibits the activity of ATP-sensitive K+ channel in MIN 6 cells. Antidiabetic.
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| Mechanism of action | Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells, and its early insulin release and short duration of action would be effective in improving postprandial hyperglycemia. |
| Synthesis | The cis-six hydrogen isoindole of take are raw material, through react to obtain cis-N-chloracetyl six hydrogen isoindole with chloroacetyl chloride, then carry out alkylation reaction with N-hydrocinnamoyl camphor sultam, products therefrom obtains Mitiglinide calcium dihydrate through hydrolysis, salify. The synthesis route of Mitiglinide calcium dihydrate (S 21403).
[1]Yuan, Z. T&Wang, S.J. Preparation method for Mitiglinide calcium hydrate.2014[2026-01-07]. |
| in vivo | Mitiglinide Calcium hydrate (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load[2].
| Animal Model: | Pregnant Wistar rats (12 weeks)[2] | | Dosage: | 0.3 mg/kg, 1 mg/kg, 3 mg/kg | | Administration: | Oral administration | | Result: | Dose-dependently suppressed AUCglucose levels. |
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Mitiglinide calcium dihydrate Preparation Products And Raw materials
