MK-5172 CAS 1206524-85-7

Introduction：Basic information about MK-5172 CAS 1206524-85-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

MK-5172 Basic information

• Product Name: MK-5172
• Synonyms: MK-5172;(1aR,5S,8S,10R,22aR)-5-(1,1-Dimethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid;8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid, 5-(1,1-diMethylethyl)-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-Methoxy-3,6-dioxo-,(1aR,5S,8S,10R,22aR)-;(1aR,5S,8R,10S,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid;Grazoprevir Intermediate 5;(33R,35S,91R,92R,5S)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxylicacid;(1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid;MK-5172 intermidiate
• CAS: 1206524-85-7
• MF: C29H38N4O7
• MW: 554.63
• EINECS: 943-551-0
• Product Categories: intermediates;MK-5172 intermediate
• Mol File: 1206524-85-7.mol

MK-5172 Chemical Properties

• Melting point: 180-185oC
• Boiling point: 825.0±65.0 °C(Predicted)
• density: 1.33
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol
• form: Solid
• pka: 3.23±0.40(Predicted)
• color: White to Off-White
• Stability: Hygroscopic
• InChIKey: IVROMYPOGKZNLP-FDOFPDFBSA-N
• SMILES: N1C2C(=CC=C(OC)C=2)N=C2CCCCC[C@]3([H])C[C@@]3([H])OC(=O)N[C@@H](C(C)(C)C)C(=O)N3C[C@]([H])(OC=12)C[C@H]3C(O)=O

MK-5172 Usage And Synthesis

Uses

MK-5172 is a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.

Advantages

MK-5172 has a higher barrier to resistance than first-generation protease inhibitors and is active against most variants associated with resistance to first-generation protease inhibitors. Tolerability and safety profile are good.