MONO-METHYL POLYETHYLENE GLYCOL 5'000ACETIC ACID N-SUCCINIMIDYL ESTER CAS 92451-01-9

Introduction：Basic information about MONO-METHYL POLYETHYLENE GLYCOL 5'000ACETIC ACID N-SUCCINIMIDYL ESTER CAS 92451-01-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

MONO-METHYL POLYETHYLENE GLYCOL 5'000ACETIC ACID N-SUCCINIMIDYL ESTER Basic information

• Product Name: MONO-METHYL POLYETHYLENE GLYCOL 5'000ACETIC ACID N-SUCCINIMIDYL ESTER
• Synonyms: SUCCINIMIDYL ESTER OF CARBOXYMETHYL-PEG;O-[(N-SUCCINIMIDYLOXYCARBONYL)-METHYL]-O'-METHYL-POLYETHYLENE GLYCOL 5'000;MONO-METHYL POLYETHYLENE GLYCOL 5,000 ACETIC ACID N-SUCCINIMIDYL ESTER;MONO-METHYL POLYETHYLENE GLYCOL 5'000ACETIC ACID N-SUCCINIMIDYL ESTER;METHOXYPOLYETHYLENE GLYCOL 5,000 ACETIC ACID N-SUCCINIMIDYL ESTER;MPEGn-SCM 2K, 5K, 10K, 20K;O-[(N-succinimidyloxycarbonyl)me]-O'-me-polyeth.glycol 5000;Succinimidyl ester of carboxymethyl-PEG, mono-Methyl polyethylene glycol 5μ000 acetic acid N-succinimidyl ester
• CAS: 92451-01-9
• MF: C11H19NO8
• MW: 293.27046
• Product Categories: Polydispersed PEG;Materials Science;Monofunctional PEGs;NHS Ester;Poly(ethylene glycol) and Poly(ethylene oxide);Polymer Science;Polymers;PEG
• Mol File: 92451-01-9.mol

MONO-METHYL POLYETHYLENE GLYCOL 5'000ACETIC ACID N-SUCCINIMIDYL ESTER Chemical Properties

• storage temp.: −20°C
• form: Solid
• color: White to off-white
• α-end: methoxy
• Ω-end: NHS ester
• InChI: InChI=1S/C8H11NO6.C3H8O2/c10-3-4-14-5-8(13)15-9-6(11)1-2-7(9)12;1-5-3-2-4/h10H,1-5H2;4H,2-3H2,1H3
• InChIKey: NYXRHTOXAYVBMV-UHFFFAOYSA-N
• SMILES: O(C(C([H])([H])OC([H])([H])C([H])([H])O[H])=O)N1C(C([H])([H])C([H])([H])C1=O)=O.O(C([H])([H])[H])C([H])([H])C([H])([H])O[H]

Safety Information

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 3-10-23
• Storage Class: 11 - Combustible Solids

MONO-METHYL POLYETHYLENE GLYCOL 5'000ACETIC ACID N-SUCCINIMIDYL ESTER Usage And Synthesis

Uses

m-PEG-NHS ester (MW 2000) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.

References

[1] Jin M, et al. Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo[J]. Acta Pharmaceutica Sinica B, 2013, 3(2): 123-129.