Morachalcone A CAS 76472-88-3
Introduction：Basic information about Morachalcone A CAS 76472-88-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Morachalcone A Basic information
| Product Name: | Morachalcone A |
| Synonyms: | Morachalcone A;(2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-2-propen-1-one;2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-, (2E)- |
| CAS: | 76472-88-3 |
| MF: | C20H20O5 |
| MW: | 340.37 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 76472-88-3.mol |
Morachalcone A Chemical Properties
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder |
| color | Yellow |
Safety Information
| Description | Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells against glutamate-induced oxidative stress, with EC50 values of 35.5±1 uM. Morachalcone A exhibits potent inhibitory activity on nitric oxide production in RAW264.7 LPS-activated mouse macrophage cells with IC50 value of 16.4 microM.3. Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM).4. Morachalcone A exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. |
| Uses | Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production[1][2][3]. |
| Definition | ChEBI: Morachalcone A is a member of chalcones. |
| target | Tyrosinase | NO |
| References | [1] Brandt D R, et al. The synthetic preparation of naturally-occurring aromatase inhibitors, morachalcone A, isogemichalcone B, and isogemichalcone C[J]. Tetrahedron, 2013, 69(47): 9994-10002. [2] Kang Y J, et al. Inhibitory effects of morachalcone A on lipopolysaccharide-induced nitric oxide production in raw 264.7 cells[J]. 2009. [3] Ferlinahayati, et al. Phenolic constituents from the wood of Morus australis with cytotoxic activity. Z Naturforsch C J Biosci. 2008 Jan-Feb;63(1-2):35-9. DOI:10.1515/znc-2008-1-207 |
Morachalcone A Preparation Products And Raw materials
