MOSAPRIDE CITRATE DIHYDRATE CAS 636582-62-2

Introduction：Basic information about MOSAPRIDE CITRATE DIHYDRATE CAS 636582-62-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

MOSAPRIDE CITRATE DIHYDRATE Basic information

• Product Name: MOSAPRIDE CITRATE DIHYDRATE
• Synonyms: 4-AMino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)Methyl]-2-Morpholinyl]Methyl]benzaMide 2-Hydroxy-1,2,3-propanetricarboxylate Hydrate;Mosapride citrate salt dihydrate;4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl ]-2-morpholinyl]methyl]benzamide citrate dihydrate;Mosapride dihydrate citrate;MOSAPRIDE CITRATE DIHYDRATE USP/EP/BP;4-Amino-5-Chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate hydrate(1:1:2);GR 107719 B;GR-107719-B
• CAS: 636582-62-2
• MF: C27H33ClFN3O10
• MW: 614.0164232
• Product Categories: Agonist;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;API
• Mol File: 636582-62-2.mol

MOSAPRIDE CITRATE DIHYDRATE Chemical Properties

• Melting point: 112-114°C
• storage temp.: 2-8°C
• solubility: DMSO: ≥5mg/mL
• form: solid
• color: White to off-white
• InChIKey: HUZTYZBFZKRPFG-UHFFFAOYSA-N
• SMILES: O.O.OC(=O)CC(O)(CC(O)=O)C(O)=O.CCOc1cc(N)c(Cl)cc1C(=O)NCC2CN(CCO2)Cc3ccc(F)cc3

Safety Information

• Hazard Codes: Xi
• Risk Statements: 41
• Safety Statements: 26
• WGK Germany: 3
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Dam. 1

MOSAPRIDE CITRATE DIHYDRATE Usage And Synthesis

Chemical Properties

White Solid

Uses

A selective 5-HT4 receptor agonist. Gastroprokinetic.

Definition

ChEBI: Mosapride citrate dihydrate is a hydrate.

Biochem/physiol Actions

Mosapride is found effective against chronic gastritis, functional dyspepsia and gastro-oesophageal reflux disease. It is useful in treating many other symptoms associated with gastrointestinal disorders. Mosapride is known to improve digestive motility.

in vivo

Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility^[2].

• Animal Model: Beagle dogs^[2]
• Dosage: 0.3-3 mg/kg
• Administration: Intravenous injection; 0.3-3 mg/kg
• Result: Increased the antral motor activity dose-dependently in conscious dogs.

IC 50

5-HT₄ Receptor; Kv4.3: 15.2 μM (IC₅₀)