Introduction：Basic information about MSI-1436 CAS 186139-09-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
MSI-1436 Basic information
| Product Name: | MSI-1436 |
| Synonyms: | MSI-1436;Trodusquemine;TRODUSQUEMINE;AMINOSTEROL-1436;MSI1436;Cholestane-7,24-diol, 3-[[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-;Trodusquemine (MSI-1436);MSI-1436 USP/EP/BP;MSI-1436(Trodusquemine;MSI 1436,MSI1436 |
| CAS: | 186139-09-3 |
| MF: | C37H72N4O5S |
| MW: | 685.07 |
| EINECS: | 202-303-5 |
| Product Categories: | |
| Mol File: | 186139-09-3.mol |
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MSI-1436 Chemical Properties
| density | 1.12±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Soluble in DMSO |
| pka | -3.49±0.18(Predicted) |
| form | Solid |
| color | White to yellow |
Safety Information
MSI-1436 Usage And Synthesis
| Uses | Treatment of medically significant obesity. |
| Uses | Trodusquemine is a specific protein tyrosine phosphatase 1B (PTP1B) inhibitor. |
| Definition | ChEBI: Trodusquemine is a bile acid. |
| in vivo | MSI-1436 (10 mg/kg, i.p.) causes obesity-dependent body weight, reduces total body fat content and adipocyte size and lipid content of white adipose tissue of mice. MSI-1436 treatment significantly reduces plasma insulin levels. MSI-1436 (10 mg/kg, i.p.) increases phosphorylation of STAT-3 2.7-fold and, in conjunction with 100 U/kg insulin, p-IRβ increases threefold over insulin alone-treated rats[1]. MSI-1436 (Trodusquemine) exhibits anxiolytic effect through a restoration of endocannabinoid (eCB) signaling within the amygdala[2]. MSI-1436 (5 mg/kg, i.p.) has an anti-diabetic effect on diabetic mice, and is sufficient to suppress food intake and cause weight loss in CD1 mice[3]. |
MSI-1436 Preparation Products And Raw materials
