Introduction：Basic information about MYRISTOLEIC ACID CAS 544-64-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
MYRISTOLEIC ACID Basic information
| Product Name: | MYRISTOLEIC ACID |
| Synonyms: | MYRISTOLEIC ACID;DELTA 9 CIS TETRADECENOIC ACID;CIS-9-TETRADECENOIC ACID;C14:1 (CIS-9) ACID;9-tetradecenoic acid;(Z)-tetradec-9-enoic acid;MYRISTOLEIC ACID 99%;9-Tetradecenoic acid, (9Z)- |
| CAS: | 544-64-9 |
| MF: | C14H26O2 |
| MW: | 226.35 |
| EINECS: | 208-876-8 |
| Product Categories: | |
| Mol File: | 544-64-9.mol |
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MYRISTOLEIC ACID Chemical Properties
| Melting point | −4.5-−4 °C(lit.) |
| Boiling point | 144 °C0.6 mm Hg(lit.) |
| density | 0.9 g/mL at 25 °C(lit.) |
| refractive index | n20/D 1.4562(lit.) |
| Fp | 62 °C |
| storage temp. | -20°C |
| solubility | Benzene (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| pka | 4.78±0.10(Predicted) |
| color | Colourless |
| biological source | plant |
| Cosmetics Ingredients Functions | NOT REPORTED |
| InChI | InChI=1S/C14H26O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h5-6H,2-4,7-13H2,1H3,(H,15,16)/b6-5- |
| InChIKey | YWWVWXASSLXJHU-WAYWQWQTSA-N |
| SMILES | C(O)(=O)CCCCCCC/C=C\CCCC |
| LogP | 5.383 (est) |
| EPA Substance Registry System | 9-Tetradecenoic acid, (9Z)- (544-64-9) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
MYRISTOLEIC ACID Usage And Synthesis
| Chemical Properties | Colorless liquid. Found in fatof some seeds and in fish oil. |
| Uses | Myristoleic Acid induces apoptosis and necrosis in human prostrate cancer cell LNCaP, and is of a potential for developing an attractive new tool for the treatment of prostrate cancer. |
| Definition | ChEBI: Myristoleic acid is a tetradecenoic acid in which the double bond is at the 9-10 position and has Z configuration. Myristoleic acid has been isolated from Serenoa repens and has cytotoxic and apoptosis-inducing effects. It has a role as an apoptosis inducer, a plant metabolite and an EC 3.1.1.1 (carboxylesterase) inhibitor. It is a tetradecenoic acid and a long-chain fatty acid. It is a conjugate acid of a myristoleate. |
| in vivo | Myristoleic acid (2 mg/kg, IP every 24 h for 4 days) prevents RANKL-induced bone loss and osteoclast formation in mice[2].
| Animal Model: | C57BL/6 mice at 5 weeks[2].
| | Dosage: | 0.2, 2 mg/kg | | Administration: | IP every 24 h for 4 days. | | Result: | Co-administration of myristoleic acid suppressed generation of TRAP-positive osteoclasts induced by sRANKL and attenuated the increases in osteoclastic indices of Oc.S/BS, N.Oc/B. Pm and ES/BS in a dose-dependent manner. |
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| IC 50 | Human Endogenous Metabolite |
MYRISTOLEIC ACID Preparation Products And Raw materials
| Preparation Products | cetyl myristoleate |
