N-(2-Cyanoethyl)-N-methylaniline CAS 94-34-8

Introduction：Basic information about N-(2-Cyanoethyl)-N-methylaniline CAS 94-34-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

N-(2-Cyanoethyl)-N-methylaniline Basic information

• Product Name: N-(2-Cyanoethyl)-N-methylaniline
• Synonyms: 3-(methylphenylamino)-propanenitril;N-Methyl-N-Cyanoethyl Aniline;3-(methyl(phenyl)amino)propanenitrile;3-(METHYLPHENYLAMINO)PROPIONITRILE 97%;N-(2-CYANOETHYL)-N-METHYLANILINE / 3-(METHYLPHENYLAMINO)PROPIONITRILE;3-(N-Methyl-N-phenylamino)propiononitrile;3-(N-methylanilino)propanenitrile;N-Methyl-N-(2-cyanoethyl)aniline3-(N-Methyl-N-phenylamino)propionitrile
• CAS: 94-34-8
• MF: C10H12N2
• MW: 160.22
• EINECS: 202-325-5
• Product Categories: aniline derivatives;Intermediates of Dyes and Pigments
• Mol File: 94-34-8.mol

N-(2-Cyanoethyl)-N-methylaniline Chemical Properties

• Boiling point: 313 °C(lit.)
• density: 1.035 g/mL at 25 °C(lit.)
• refractive index: n20/D 1.56(lit.)
• Fp: 125-127°C/4mm
• storage temp.: Inert atmosphere,Room Temperature
• pka: 4.54±0.50(Predicted)
• form: clear liquid
• color: White to Yellow to Green
• Specific Gravity: 1.05
• BRN: 2803416
• CAS DataBase Reference: 94-34-8(CAS DataBase Reference)
• EPA Substance Registry System: Propanenitrile, 3-(methylphenylamino)- (94-34-8)

Safety Information

• Hazard Codes: Xn
• Risk Statements: 20/21/22-36/37/38-21/22
• Safety Statements: 26-36-36/37
• WGK Germany: 3
• TSCA: TSCA listed
• PackingGroup: III
• HS Code: 29214300

N-(2-Cyanoethyl)-N-methylaniline Usage And Synthesis

Synthesis

An activated carbon-supported platinum catalyst (Pt / C, 0.06 mg platinum, 0.0003 mmol, 0.1 mol percent) was added to a 10 mL Schlenk tube; after the evacuation of argon, add 1 mL of solvent (toluene). Under argon protection, to the above system, Were successively added phenylsilane (78.9 mg, 0.75 mmol), 3-Anilinopropionitrile (43.9 mg, 0.3 mmol) and formic acid (27.6 mg, 0.6 mmol). The whole anti-reaction was carried out at 80 ° C with stirring for 15 hours. After completion of the reaction, 3 mL of ethyl acetate was added to the system. The reaction was quenched with aqueous sodium hydroxide (3 mol / L, 3 mL). Ethyl acetate (3 x 10 mL), the organic phase was separated, Dried over anhydrous Na2SO4, and filtered; the solvent was removed by rotary evaporation. The residue was purified by column chromatography on ethyl acetate/petroleum ether = 1: 50 mixed solvent. Separation and purification gave N-(2-Cyanoethyl)-N-methyl aniline 226.4 mg, yield of 55 per cent.

References

[1] Journal of Organic Chemistry, 2015, vol. 80, # 20, p. 10375 - 10379
[2] Tetrahedron, 2013, vol. 69, # 6, p. 1712 - 1716
[3] Green Chemistry, 2010, vol. 12, # 5, p. 786 - 789
[4] Synthesis, 2008, # 24, p. 3931 - 3936
[5] Journal of the American Chemical Society, 1944, vol. 66, p. 725,728

N-(2-Cyanoethyl)-N-methylaniline Preparation Products And Raw materials

• Raw materials: Formic acid-->Acrylonitrile-->N-Methylaniline-->3-Anilinopropionitrile-->Acetonitrile
• Preparation Products: Basic Blue 162-->Disperse Orange 25:1-->Basic Blue 162-->Benzeneethanaminium, 4-[2-[4-[(2-cyanoethyl)methylamino]phenyl]diazenyl]-N,N,N-trimethyl-β-oxo-, chloride (1:1)