N-(2-Hydroxyethyl)adenosine CAS 4338-48-1

Introduction：Basic information about N-(2-Hydroxyethyl)adenosine CAS 4338-48-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

N-(2-Hydroxyethyl)adenosine Basic information

Product Name:N-(2-Hydroxyethyl)adenosine
Synonyms:NSC 54251;(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-di;N-(2-Hydroxyethyl)adenosine;6-Hydroxyethyladenosine;N6-(2-Hydroxyethyl)adenosine;(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)aMino)-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol;(2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4;Adenosine, N-(2-hydroxyethyl)-
CAS:4338-48-1
MF:C12H17N5O5
MW:311.29
EINECS:200-001-2
Product Categories:
Mol File:4338-48-1.mol

N-(2-Hydroxyethyl)adenosine Chemical Properties

Melting point 194-195℃
Boiling point 725.8±70.0 °C(Predicted)
density 1.88
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka13.11±0.70(Predicted)
color White to Off-White
InChIInChI=1S/C12H17N5O5/c18-2-1-13-10-7-11(15-4-14-10)17(5-16-7)12-9(21)8(20)6(3-19)22-12/h4-6,8-9,12,18-21H,1-3H2,(H,13,14,15)/t6-,8-,9-,12-/m1/s1
InChIKeyBBOCDRLDMQHWJP-WOUKDFQISA-N
SMILESOC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NCCO)N=C2)[C@H](O)[C@@H]1O

Safety Information

N-(2-Hydroxyethyl)adenosine Usage And Synthesis

N-(2-Ethoxyphenyl)-N'-(4-ethylphenyl)-ethlyene diamide CAS 23949-66-8
N-(2-Hydroxyethyl)ethylenediaminetriacetic acid CAS 150-39-0
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UsesN-(2-Hydroxyethyl)adenosine has been studied as an anticonvulsant through the activation of adenosine A1 receptor (AA1R).
in vivo

N6-(2-Hydroxyethyl)adenosine (20-40 mg/kg, ip, once daily for 6 weeks) reduces the blood glucose level and diabetes-induced kidney damage, increases the activities of antioxidant enzymes (such as SOD, catalase CAT and GSH) in renal tissue, reduces the level of malondialdehyde (MDA), exhibits anti-inflammatory and antioxidant activities, and ameliorates Alloxan (HY-W017227)-induced diabetes in rats models[2].
N6-(2-Hydroxyethyl)adenosine (75-150 mg/kg, po, once daily for 19 days) exhibits antitumor effect in SGC-7901 xenograft mouse models[4].

Animal Model:Alloxan-induced diabetes in rats models[2]
Dosage:20-40 mg/kg
Administration:ip, once daily for 6 weeks
Result:Reduced the levels of blood glucose, serum creatinine (Scr), blood urea nitrogen (BUN) and urine protein.
Reduced the levels of TNF-α, IL-1β, IL-6, TGF-β1 and NF-κB in kidney tissue.
Alleviated the damage of glomeruli and renal tubules.
Animal Model:SGC-7901 xenograft mouse models[4]
Dosage:75-150 mg/kg
Administration:po, once daily for 19 days
Result:Reduced tumor volume and weight.

N-(2-Hydroxyethyl)adenosine Preparation Products And Raw materials

Raw materials6-(BETA-HYDROXYETHYLAMINO)-PURINE-->6-Hydroxypurine-->Inosine