N-(2-Hydroxyethyl)ethylenediaminetriacetic acid CAS 150-39-0

Introduction：Basic information about N-(2-Hydroxyethyl)ethylenediaminetriacetic acid CAS 150-39-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

N-(2-Hydroxyethyl)ethylenediaminetriacetic acid Basic information

• Product Name: N-(2-Hydroxyethyl)ethylenediaminetriacetic acid
• Synonyms: N-(2-HYDROXYETHYL)ETHYLENEDIAMINE-N,N,N''-TRIACETIC ACID (HEDTA);N-(2-Hydroxyethyl)ethylenediaminetriacetic acid, 98+%;HEDTA, HEEDTA, N-Carboxymethyl-Nμ-(2-hydroxyethyl)-N,Nμ-ethylenediglycine;(2-Hydroxyethyl)ethylenediaminetriacetic acid, trisodium salt;Trisodium hydroxyethyl ethylenediaminetriacetate;2-[Carboxymethyl(2-hydroxyethyl)amino]ethyliminodiacetic acid;N-(2-Hydroxyethyl)ethylenediaminetriacetic acid,99%;N-Carboxymethyl-N′-(2-hydroxyethyl)-N
• CAS: 150-39-0
• MF: C10H18N2O7
• MW: 278.26
• EINECS: 205-759-3
• Product Categories: Analytical Chemistry;Chelating Reagents;Complexones;EDTA Analogs;150-39-0
• Mol File: 150-39-0.mol

N-(2-Hydroxyethyl)ethylenediaminetriacetic acid Chemical Properties

• Melting point: 212 °C (dec.)(lit.)
• Boiling point: 421.08°C (rough estimate)
• density: 1.3300 (rough estimate)
• vapor pressure: 0.01Pa at 20℃
• refractive index: 1.4550 (estimate)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: 3  M NaOH: 0.1 M, clear, colorless
• form: powder to crystal
• pka: pK1:2.39;pK2:5.37;pK3:9.93 (25°C)
• color: White to Almost white
• Water Solubility: soluble
• BRN: 1804795
• Cosmetics Ingredients Functions: BULKING CHELATING ABSORBENT OPACIFYING VISCOSITY CONTROLLING
• Cosmetic Ingredient Review (CIR): N-(2-Hydroxyethyl)ethylenediaminetriacetic acid (150-39-0)
• InChI: 1S/C10H18N2O7/c13-4-3-11(5-8(14)15)1-2-12(6-9(16)17)7-10(18)19/h13H,1-7H2,(H,14,15)(H,16,17)(H,18,19)
• InChIKey: URDCARMUOSMFFI-UHFFFAOYSA-N
• SMILES: OCCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O
• LogP: -4.65 at 20℃
• CAS DataBase Reference: 150-39-0(CAS DataBase Reference)
• EPA Substance Registry System: (2-Hydroxyethyl)ethylenediaminetriacetic acid (150-39-0)

Safety Information

• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-22-40-20/21/22
• Safety Statements: 26-37/39-36-22
• WGK Germany: -
• RTECS: MB9185000
• TSCA: TSCA listed
• HS Code: 29224999
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2
• Hazardous Substances Data: 150-39-0(Hazardous Substances Data)

N-(2-Hydroxyethyl)ethylenediaminetriacetic acid Usage And Synthesis

Chemical Properties

Crystalline

Uses

Chelating compound.

Uses

N-(2-Hydroxyethyl)ethylenediaminetriacetic acid is a chelating agent.

in vivo

EDTA-OH (50 mg/kg, i.p. for 5 days) decreases the aluminium concentration in blood and brain and oxidative stress in brain. EDTA-OH is blood-brain barrier permeable, which could be an antidote for aluminium overload^[3].

• Animal Model: Aluminium overload in wistar rats^[3]
• Dosage: 50 mg/kg
• Administration: i.p. for 5 days
• Result: Inhibited GST activity, reduced the concentration of aluminium in blood and brain.

Purification Methods

Crystallise HEDTA from warm H2O, after filtering, by addition of 95% EtOH and allowing to cool. The crystals, collected on a sintered-glass funnel, are washed three times with cold absolute EtOH, then again crystallised from H2O. After leaching with cold H2O, the crystals are dried at 100o under vacuum. [Spedding et al. J Am Chem Soc 78 34 1956, Beilstein 4 IV 2449.]