Introduction：Basic information about N,O-Dimethylhydroxylamine hydrochloride CAS 6638-79-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
N,O-Dimethylhydroxylamine hydrochloride Basic information
| Product Name: | N,O-Dimethylhydroxylamine hydrochloride |
| Synonyms: | N,O-DiMethylhydroxylaMine Hyd;MethanaMine,N-Methoxy-, hydrochloride (1:1);N,O-Dimethylhydroxylamine Hydrochloride;N,O-dimehtylhydroxylamine.HCL;N,O-Dimethylhydroxylamine hydrochloride≥ 99% (GC);O-Dimethylhydroxylamine hydrochloride;CAS:6638-79-5;n,o-dimethylhydroxylamine hydrochloride cas 6638-79-5 |
| CAS: | 6638-79-5 |
| MF: | C2H8ClNO |
| MW: | 97.54 |
| EINECS: | 229-642-1 |
| Product Categories: | Aliphatics;Amines;Active Esters/Additives;Coupling;Synthetic Reagents;Amination;Hydroxylamines;Hydroxylamines (N-Substituted);Hydroxylamines (O-Substituted);Synthetic Organic Chemistry;API intermediates;1;3;bc0001;6638-79-5 |
| Mol File: | 6638-79-5.mol |
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N,O-Dimethylhydroxylamine hydrochloride Chemical Properties
| Melting point | 112-115 °C |
| storage temp. | Store below +30°C. |
| solubility | DMSO, Methanol |
| form | Crystalline Powder or Crystals |
| color | White to off-white |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| BRN | 3650353 |
| InChI | InChI=1S/C2H7NO.ClH/c1-3-4-2;/h3H,1-2H3;1H |
| InChIKey | USZLCYNVCCDPLQ-UHFFFAOYSA-N |
| SMILES | N(C)OC.Cl |
| CAS DataBase Reference | 6638-79-5(CAS DataBase Reference) |
| EPA Substance Registry System | Methanamine, N-methoxy-, hydrochloride (6638-79-5) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/38-36/37/38 |
| Safety Statements | 26-36-24/25 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HS Code | 29280090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
N,O-Dimethylhydroxylamine hydrochloride Usage And Synthesis
| Chemical Properties | N,O-Dimethylhydroxylamine hydrochloride is white to off-white crystals or crystalline powder |
| Uses | N,O-Dimethylhydroxylamine hydrochloride is used for preparation of an inhibitor of the NLS-derived BC peptides. |
| Uses | N,O-Dimethylhydroxylamine hydrochloride is used as a reagent in the preparation of 2-acyloxazoles from 2-oxazolemagnesium chloride and N-methoxy-N-methyl-3-oxo-butyramide from diketene. It is also used in amide coupling reactions to form Weinreb amides, which are useful in the Weinreb ketone synthesis. In addition, it is used in the preparation of an inhibitor of the NLS-derived BC peptides. |
| Uses | Reagent for the preparation of Weinreb amides recently used in the synthesis of 2-acyloxazoles from 2-oxazolemagnesium chloride. |
| Synthesis | N,O-Dimethylhydroxylamine hydrochloride was synthesised by methylation, saponification and decarboxylation reactions using chloroformate ester (I) as the starting material. The specific reaction procedure is as follows: First, hydroxylamine hydrochloride is used to treat chloroformate (I). The resulting N-ethoxycarbonylhydroxylamine (II) is then subjected to methylation. Compound (III) undergoes saponification and decarboxylation to yield N,O-Dimethylhydroxylamine hydrochloride (IV).
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N,O-Dimethylhydroxylamine hydrochloride Preparation Products And Raw materials
| Preparation Products | 1-(4-ACETYLPIPERIDINO)ETHAN-1-ONE-->N-methylquinolin-2-amine-->DIETHYL (N-METHOXY-N-METHYLCARBAMOYLMETHYL)PHOSPHONATE-->N-Methoxy-N-methylnicotinamide-->N-Methoxy-N,1-diMethylpiperidine-4-carboxaMide-->N,N-DIMETHYLHEXANAMIDE-->4,N-DIMETHYL-N-METHOXYBENZAMIDE-->N-methoxy-N-methyl-2-(4-nitrophenyl)acetamide-->(R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine-->4-IODO-N-METHOXY-N-METHYL-BENZAMIDE-->TERT-BUTYL 3-(METHOXY(METHYL)CARBAMOYL)PYRROLIDINE-1-CARBOXYLATE-->5-Isoxazolecarboxamide,N-methoxy-N-methyl-(9CI) |
