Introduction：Basic information about N-2-(4-bromobenzhydryloxy)ethyldimethylamine CAS 118-23-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
N-2-(4-bromobenzhydryloxy)ethyldimethylamine Basic information
| Product Name: | N-2-(4-bromobenzhydryloxy)ethyldimethylamine |
| Synonyms: | bromazine;bromodiphenhydramine;N-2-(4-bromobenzhydryloxy)ethyldimethylamine;Ethanamine, 2-(4-bromophenyl)phenylmethoxy-N,N-dimethyl-;Bromanautine;Bromo-Benadryl;Histabromamine;Diphenhydramine EP Impurity C |
| CAS: | 118-23-0 |
| MF: | C17H20BrNO |
| MW: | 334.25 |
| EINECS: | 204-238-8 |
| Product Categories: | |
| Mol File: | 118-23-0.mol |
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N-2-(4-bromobenzhydryloxy)ethyldimethylamine Chemical Properties
| Boiling point | 151-154 °C(Press: 0.3 Torr) |
| density | 1.259±0.06 g/cm3(Predicted) |
| pka | pKa 8.64(H2Ot = 25c = 0.002 to 0.01) (Uncertain) |
Safety Information
N-2-(4-bromobenzhydryloxy)ethyldimethylamine Usage And Synthesis
| Originator | Bromazine,Shanghai LanshengCorporation |
| Uses | Antihistaminic. |
| Definition | ChEBI: A tertiary amino compound that is the 4-bromobenzhydryl ether of 2-(dimethylamino)ethanol. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies. |
| Manufacturing Process | 28.1 parts of p-bromobenzhydrylbromide are heated to boiling, under refluxand with stirring, with 50 parts of ethylene chlorohydrin and 5.3 parts ofcalcined sodium carbonate. The reaction product is extracted with ether andthe etheral solution washed with water and dilute hydrochloric acid. Theresidue from the solution in ether [p-bromobenzhydryl(β-chloroethyl)ether].
28.1 parts of this ether are heated with 12 parts of dimethylethylamine in asealed tube for 4 hours at 110°C. The product of the reaction is extractedseveral time with dilute hydrochloric acid. The acid solution made alkaline, inthe cold, with concentrated caustic soda solution, and the base whichseparates taken up in ether. The ether extract is washed with concentratedpotassium carbonate solution, evaporated down, and the residue distilled invacuo. Boiling point of p-bromo-α-phenylbenzyloxy)-N,N-dimethylethylamine151-154°C under 0.3 mm.
p-Bromo-α-phenylbenzyloxy)-N,N-dimethylethylamine may be used as ahydrochloride. |
| Brand name | Ambodryl. |
| Therapeutic Function | Antihistaminic |
N-2-(4-bromobenzhydryloxy)ethyldimethylamine Preparation Products And Raw materials
| Raw materials | 2-Chloroethanol-->N,N-Dimethylethylamine |
