Introduction：Basic information about N3-PEG7-OH CAS 1274892-60-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
N3-PEG7-OH Basic information
| Product Name: | N3-PEG7-OH |
| Synonyms: | N3-PEG7-OH;Azido-PEG7-OH;20-azido-3,6,9,12,15,18-hexaoxaicosan-1-ol;N3-PEG7-OH/3,6,9,12,15,18-Hexaoxaeicosan-1-ol, 20-azido-;N?-PEG7-OH |
| CAS: | 1274892-60-2 |
| MF: | C14H29N3O7 |
| MW: | 351.4 |
| EINECS: | |
| Product Categories: | peg |
| Mol File: | 1274892-60-2.mol |
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N3-PEG7-OH Chemical Properties
| storage temp. | Store at Room Tem. |
| solubility | Soluble in Water, DMSO, DCM, DMF |
| InChI | InChI=1S/C14H29N3O7/c15-17-16-1-3-19-5-7-21-9-11-23-13-14-24-12-10-22-8-6-20-4-2-18/h18H,1-14H2 |
| InChIKey | IKLKCSJOBKMTTI-UHFFFAOYSA-N |
| SMILES | C(COCCOCCOCCO)OCCOCCOCCN=[N+]=[N-] |
Safety Information
N3-PEG7-OH Usage And Synthesis
| Description | Azido-PEG7-alcohol is a aqueous soluble PEGylation reagent The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Hydroxy group further increase the reagnt's water solubility. |
| Uses | Azido-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG7-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. |
| IC 50 | PEGs |
| References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
N3-PEG7-OH Preparation Products And Raw materials
