N-Acetyl-L-leucine CAS 1188-21-2

Introduction：Basic information about N-Acetyl-L-leucine CAS 1188-21-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

N-Acetyl-L-leucine Basic information

• Product Name: N-Acetyl-L-leucine
• Synonyms: AKOS BBS-00004735;ACETYL-DL-LEUCINE, N-;ACETYL-DL-LEUCINE;ACETYL-L-LEUCINE;AC-DL-LEU-OH;AC-LEUCINE;AC-LEU-OH;IFLAB-BB F0777-0821
• CAS: 1188-21-2
• MF: C8H15NO3
• MW: 173.21
• EINECS: 214-706-3
• Product Categories: N-Acetyl-Amino acid series;Amino Acid Derivatives;Leucine;Peptide Synthesis;Leucine [Leu, L];Amino Acids and Derivatives;Ac-Amino Acids;Amino Acids (N-Protected);Biochemistry;Amino Acid Derivatives;Amino Acids;Amino Acids Derivatives;amino acid;amino;bc0001;1188-21-2
• Mol File: 1188-21-2.mol

N-Acetyl-L-leucine Chemical Properties

• Melting point: 187-190 °C(lit.)
• alpha: -24.5 º (c=4, MeOH)
• Boiling point: 303.86°C (rough estimate)
• density: 1.1599 (rough estimate)
• refractive index: -22 ° (C=5, EtOH)
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMSO (Slightly), Ethanol (Slightly), Water (Slightly, Heated)
• pka: 3.67±0.10(Predicted)
• form: Crystalline Powder
• color: White
• Optical Rotation: [α]25/D 23±3°, c = 2 in ethanol
• Water Solubility: 0.81 g/100 mL (20 ºC)
• BRN: 1724849
• Major Application: peptide synthesis
• InChI: 1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1
• InChIKey: WXNXCEHXYPACJF-ZETCQYMHSA-N
• SMILES: CC(C)C[C@H](NC(C)=O)C(O)=O
• CAS DataBase Reference: 1188-21-2(CAS DataBase Reference)
• NIST Chemistry Reference: L-leucine, n-acetyl-(1188-21-2)
• EPA Substance Registry System: L-Leucine, N-acetyl- (1188-21-2)

Safety Information

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• TSCA: TSCA listed
• HazardClass: IRRITANT
• HS Code: 29241900
• Storage Class: 11 - Combustible Solids

N-Acetyl-L-leucine Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.

Definition

ChEBI: The N-acetyl derivative of L-leucine.

reaction suitability

reaction type: C-H Activation
reaction type: solution phase peptide synthesis
reagent type: catalyst
reaction type: Peptide Synthesis

in vivo

Levacetylleucine (60 mg/kg, i.v., administration on days 1, 2 and 3 for 15 days) decreases the postural imbalance scores and accelerates the course of postural compensation induced by UL in rats^[3].
Levacetylleucine (100 mg/kg, oral gavage, administration daily for 28 days) attenuates cortical cell death afer traumatic brain injury (TBI) in N-Acetyl-L-leucine-treated TBI mouse cortices^[4].