NADP sodium salt CAS 1184-16-3

Introduction：Basic information about NADP sodium salt CAS 1184-16-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

NADP sodium salt Basic information

• Product Name: NADP sodium salt
• Synonyms: β-NicotinaMide Adenine Dinucleotide Phosphate SodiuM Salt Hydrate (~90%);beta-Nicotinamide adenine dinucleotide phosphate sodium salt beta-NADP sodium salt;NADP, MONOSODIUM SALT;NADP SODIUM SALT;CO II, NA;COENZYME II SODIUM SALT;BETA-NADP MONOSODIUM SALT;BETA-NADP-NA
• CAS: 1184-16-3
• MF: C21H29N7NaO17P3
• MW: 767.41
• EINECS: 214-664-6
• Product Categories: Enzymes and Coenzymes in Nucleic Acids;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Vitamin Related Compounds;Vitamins;nucleoside;1184-16-3
• Mol File: 1184-16-3.mol

NADP sodium salt Chemical Properties

• Melting point: 175-178 °C (dec.)(lit.)
• storage temp.: -20°C
• solubility: H₂O: 50 mg/mL
• form: powder
• color: off-white to yellow
• PH: 2.0-4.0
• Water Solubility: Soluble in water.
• Merck: 14,6344
• BRN: 4779954
• InChIKey: JNUMDLCHLVUHFS-QYZPTAICSA-M
• SMILES: [Na+].[H]O[H].NC(=O)c1ccc[n+](c1)C2O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@@H]([C@@H]3O)P(O)(O)=O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O

Safety Information

• Hazard Codes: Xn,Xi
• Risk Statements: 36-36/37/38
• Safety Statements: 22-24/25-37/39-36-26
• WGK Germany: 3
• RTECS: UU3440000
• HS Code: 29349990
• Storage Class: 11 - Combustible Solids

NADP sodium salt Usage And Synthesis

Description

NADP sodium salt is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source').It is used by all forms of cellular life.

Chemical Properties

White to slightly yellowish powder

Uses

β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions.
β-Nicotinamide Adenine Dinucleotide Phosphate Sodium Salt Hydrate is a substrate NADP which plays a role in a variety of metabolic processes.

Uses

NADP sodium salt acts as an electron acceptor used by cells. It is also useful in vitro to study NADP. Furthermore, it is used in a wide range of enzyme catalyzed oxidation reduction reactions. The combination of NADP+/NADPH is employed in a variety of antioxidation mechanisms, which protect against reactive oxidation species accumulation.

Biosynthesis

A process for preparing NADP sodium salt comprising performing phosphorylation using a polyphosphoric acid or a salt thereof and nicotinamide adenine dinucleotide (NAD+) as substrates in the presence of a polyphosphate-dependent NAD+ kinase from a Mycobacterium, wherein the reaction solution contains 0.1-15% by weight of the polyphosphoric acid or a salt thereof, and 5-150 mM of a divalent metal ion.

Biological Functions

NADP sodium salt is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. It plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes.

Biochem/physiol Actions

Electron acceptor

Mechanism of action

NADP sodium salt exerts its effect by competitively inhibiting nucleotide metabolism through the suppression of enzymes like nucleoside diphosphate kinase (NDPK) and adenosine kinase (ADK). Additionally, it serves as a substrate for enzymes like DNA polymerases and RNA polymerases, enabling the integration of NADP monosodium salt into nucleic acids during replication and transcription.

Synthesis

Pyridine nucleotide triphosphate, coenzyme II (NADP sodium salt) can be obtained from NADP+ by accepting the gamma-phosphate group of ATP catalyzed by a kinase.