Introduction：Basic information about N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 CAS 2107273-62-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 Basic information
| Product Name: | N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 |
| Synonyms: | N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3;2-(3-(5-((2,5,8,11-Tetraoxatridecan-13-yl)oxy)-1,3,3-trimethylindolin-2-ylidene)prop-1-en-1-yl)-5-((3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy)-1,3,3-trimethyl-3H-indol-1-ium chloride |
| CAS: | 2107273-62-9 |
| MF: | C45H65ClN2O10 |
| MW: | 829.47 |
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| Product Categories: | |
| Mol File: | 2107273-62-9.mol |
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N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 Chemical Properties
| solubility | Soluble in Water, DMSO, DMF, DCM |
Safety Information
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 Usage And Synthesis
| Description | N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a PEG linker containing cyanine dye with excitation/emmission maximum 555/570 nm and an alkyne group, which enables copper-catalyzed Click Chemistry. The hydophilic PEG spacer increases solubility in aqueous media. |
| Uses | N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. |
| IC 50 | PEGs |
| References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 Preparation Products And Raw materials
