NOSCAPINE HYDROCHLORIDE CAS 912-60-7

Introduction：Basic information about NOSCAPINE HYDROCHLORIDE CAS 912-60-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

NOSCAPINE HYDROCHLORIDE Basic information

• Product Name: NOSCAPINE HYDROCHLORIDE
• Synonyms: NOSCAPINE HYDROCHLORIDE;NARCOTINE HYDROCHLORIDE;,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))-;1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1;1-alpha-narcotinehydrochloride;capvalhydrochloride;coscopinhydrochloride;coscotabshydrochloride
• CAS: 912-60-7
• MF: C22H24ClNO7
• MW: 449.88
• EINECS: 213-014-9
• Product Categories: Inhibitors
• Mol File: 912-60-7.mol

NOSCAPINE HYDROCHLORIDE Chemical Properties

• Melting point: 221-223 °C(lit.)
• storage temp.: 2-8°C
• solubility: Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.
• form: Solid
• color: Crystals
• Merck: 13,6752
• Major Application: food and beverages
• InChIKey: MFLVZFXCSKVCSH-FSKSRBAZNA-N
• SMILES: C12=C(CCN(C)[C@@]1([H])[C@@]1([H])OC(=O)C3C(OC)=C(OC)C=CC1=3)C=C1OCOC1=C2OC.Cl |&1:6,8,r|
• EPA Substance Registry System: 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7)

Safety Information

• Hazard Codes: Xn,Xi
• Risk Statements: 22
• Safety Statements: 36
• RIDADR: 1544
• WGK Germany: 3
• RTECS: NP7225000
• F: 10
• HS Code: 2939.19.5000
• HazardClass: 6.1(b)
• PackingGroup: III
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral STOT SE 3
• Toxicity: cyt-ham:fbr 60 mg/L ESKHA5 96,55,78

NOSCAPINE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder or colourless crystals, hygroscopic.

Uses

topical fluoroquinolone antibiotic for acne

Uses

Anti-Tussive

Uses

Noscapine Hydrochloride is a bradykinin B and tubulin inhibitor. Anti-viral.

Biological Activity

Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.

Safety Profile

Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.

in vivo

Noscapine (300?mg/kg; oral gavage; daily; for 15 days; athymic female mice) hydrochloride treatment reduces tumor growth in mice^[1].

• Animal Model: Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells^[1]
• Dosage: 300?mg/kg
• Administration: Oral gavage; daily; for 15 days
• Result: Revealed a significant reduction of tumor volume.