Octadecylphosphonic acid CAS 4724-47-4
Octadecylphosphonic acid Basic information
| Product Name: | Octadecylphosphonic acid |
| Synonyms: | n-Octadecylphosphonic acid, 98 %;Octadecanephosphonic acid;octadecylphosphonic acid;N-OCTADECYLPHOSPHONIC ACID, 93+%;n-Octadecylphosphonicacid,min.97%;n-Octadecylphosphonic acid,min. 97%;stearylphosphonic acid;1-Octadecylphosphonic acid |
| CAS: | 4724-47-4 |
| MF: | C18H39O3P |
| MW: | 334.47 |
| EINECS: | 225-216-4 |
| Product Categories: | organic phosphonic acid;API intermediates |
| Mol File: | 4724-47-4.mol |
Octadecylphosphonic acid Chemical Properties
| Melting point | 99℃ |
| Boiling point | 463.6±28.0 °C(Predicted) |
| density | 0.969 |
| storage temp. | Store at room temperature |
| pka | 2?+-.0.10(Predicted) |
| form | Crystalline |
| color | White to off-white |
| Water Solubility | Insoluble in water. |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| InChI | InChI=1S/C18H39O3P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22(19,20)21/h2-18H2,1H3,(H2,19,20,21) |
| InChIKey | FTMKAMVLFVRZQX-UHFFFAOYSA-N |
| SMILES | P(CCCCCCCCCCCCCCCCCC)(=O)(O)O |
| CAS DataBase Reference | 4724-47-4 |
| EPA Substance Registry System | Phosphonic acid, octadecyl- (4724-47-4) |
Safety Information
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HS Code | 29319090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
| Uses | Octadecylphosphonic acid is used as detergents, dispersants, emulsifiers, and chelating agents. Alkyl phosphonic acids are typically sparingly soluble in both organic solvents and water, but become more soluble in water when neutralized to phosphonates at neutral to high pH. |
| Chemical Properties | crystalline solid |
| Uses | n-Octadecylphosphonic acid is used in thermal paper for receipts, adding machines and tickets. It acts as surfactant, emulsifier, dispersants and chelating agents. Further, it is a long chain phosphonic acid compound utilized for proteomics research. In addition to this, it is used to prepare modified mesoporous magnetic nano particles through Lewis acid/base interaction. |
| General Description | Octadecylphosphonic acid (OPA) is used as a self-assembled monolayer that forms a surfactant which strongly bonds with the surface atoms of different metal oxides. It provides hydrophobic properties and covers a higher surface area than the predominantly used silanes. |
| Synthesis | 16165-72-3 4724-47-4 Under argon protection, octadecyl diethyl phosphite (1.2 g) was added to a Schlenk flask with 10 mL of dichloromethane. TMSBr (2.0 g, 4 mmol) was added slowly via syringe and the reaction mixture was stirred overnight at room temperature. The following day, dichloromethane and unreacted TMSBr were removed by distillation under reduced pressure. 15 mL of methanol was added to the residue and stirring was continued for 3 hr. Subsequently, methanol was evaporated under reduced pressure to give an off-white crystalline solid. The crude product was dissolved in boiling hexane with vigorous stirring and left to partition, cooled to room temperature and filtered. This purification process was repeated three times for complete removal of oily impurities, resulting in a white solid product. The product was characterized as follows: 1H NMR (CDCl3, ppm, J Hz): δ 8.73 (br, 2H, OH), 1.90 (m, 2H, PCH2, J = 26.75), 1.616 (br, 2H, CH2), 1.39 (br, 2H, CH2), 1.19 (s, 30H, CH2-alkyl), 0.877 (t, 3H, CH3, J = 13.0). Mass spectrum: [M+] = 334.26. Elemental analysis: C18H39O3P, calculated values: C, 64.64; H, 11.75; measured values: C, 64.62; H, 11.72. |
| References | [1] Bulletin of the Chemical Society of Ethiopia, 2014, vol. 28, # 1, p. 143 - 148 [2] Phosphorus, Sulfur and Silicon and Related Elements, 2002, vol. 177, # 4, p. 877 - 891 [3] Chemistry of Materials, 2018, vol. 30, # 21, p. 8034 - 8039 |
Octadecylphosphonic acid Preparation Products And Raw materials
| Raw materials | Diethyl-n-Octadecylphosphonate, 98 %-->Bromotrimethylsilane-->Dichloromethane |
