Introduction：Basic information about Oxamic acid sodium salt CAS 565-73-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Oxamic acid sodium salt Basic information
| Product Name: | Oxamic acid sodium salt |
| Synonyms: | aminooxo-aceticacimonosodiumsalt;AMINOOXOACETIC ACID SODIUM SALT;OXALIC ACID MONOAMIDE SODIUM SALT;OXAMIC ACID SODIUM SALT;SODIUM OXAMATE;oxamic acid sodium;OxamicacidsodiumsaltOxamicacidsodiumsalt;Aminooxoacetic acid sodium salt, Oxalic acid monoamide sodium salt, Oxamic acid sodium salt |
| CAS: | 565-73-1 |
| MF: | C2H2NNaO3 |
| MW: | 111.03 |
| EINECS: | 209-290-5 |
| Product Categories: | |
| Mol File: | 565-73-1.mol |
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Oxamic acid sodium salt Chemical Properties
| Melting point | 300 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | PBS (pH 7.2): 10 mg/ml |
| form | solid |
| color | White to off-white |
| biological source | synthetic (organic) |
| Water Solubility | Soluble in water (10 mg/ml). |
| BRN | 6538153 |
| InChI | InChI=1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1 |
| InChIKey | RQVZIJIQDCGIKI-UHFFFAOYSA-M |
| SMILES | C(=O)(N)C([O-])=O.[Na+] |
| CAS DataBase Reference | 565-73-1(CAS DataBase Reference) |
| EPA Substance Registry System | Sodium oxamate (565-73-1) |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 10 |
| TSCA | TSCA listed |
| HS Code | 29241990 |
| Storage Class | 11 - Combustible Solids |
Oxamic acid sodium salt Usage And Synthesis
| Description | Oxamic acid sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis. Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells. |
| Chemical Properties | white crystalline powder |
| Uses | Oxamic acid sodium salt is a lactate dehydrogenase (LDH) inhibitor. It is a suitable compound to investigate cancer cells that utilize the glycolytic pathway.This compound is suitable for lactate dehydrogenase (LDH) related research. It can be used as an inhibitor of gluconeogenesis useful for anticancer research. |
| Application | Sodium oxamate, an inhibitor of LDH-C4, prevented the AR induced by lysophosphatidylcholine (LPC) or NADH. Oxamic acid sodium salt is an lactic acid dehydrogenase. Sperm suspension and cytosol fraction activities were inhibited by sodium oxamate. As cancer cells are often dependent on glycolysis for ATP production, sodium oxamate has implications as an anticancer compound. |
| Biochem/physiol Actions | Sodium oxamate influences the fatty acid metabolism. It might be useful for the treatment of diabetes. |
| in vitro | Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells.Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells.Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells.Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells.Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells. |
Oxamic acid sodium salt Preparation Products And Raw materials
| Raw materials | Ethanol-->Sodium hydroxide-->Ethyl acetate-->Tetrahydrofuran-->Toluene-->Ammonia-->Diethyl oxalate-->Ethyl chlorooxoacetate-->ETHYL OXAMATE |
