Introduction：Basic information about Oxipurinol CAS 2465-59-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Oxipurinol Basic information
| Product Name: | Oxipurinol |
| Synonyms: | 4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine, 98+%;4,6-Dihydropyrazolo Pyrimidine;4,6-Dihydroxypyrazolo[3,4-d]pyrimidine,99%;4,6-Dihydroxypyrazolo[3,4-d]pyriMidine (Oxypurinol);OXYPURINOL;OXIPURINOL;4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine;4,6-Dioxopyrazolo[3,4-d]pyrimidine |
| CAS: | 2465-59-0 |
| MF: | C5H4N4O2 |
| MW: | 152.11 |
| EINECS: | 219-570-9 |
| Product Categories: | Heterocycles, Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Bases & Related Reagents;Nucleotides;Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides;Nucleotides and Nucleosides;Pyridines, Pyrimidines, Purines and Pteredines |
| Mol File: | 2465-59-0.mol |
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Oxipurinol Chemical Properties
| Melting point | 300 °C |
| Boiling point | 274.55°C (rough estimate) |
| density | 1.637 |
| refractive index | 1.8500 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO. |
| pka | pKa 7.7 (Uncertain) |
| form | Powder |
| color | Light yellow |
| BRN | 139956 |
| Stability: | Hygroscoipic |
| InChI | InChI=1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11) |
| InChIKey | HXNFUBHNUDHIGC-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(=O)C2C=NNC=2N1 |
| CAS DataBase Reference | 2465-59-0(CAS DataBase Reference) |
| EPA Substance Registry System | Oxypurinol (2465-59-0) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29335990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
Oxipurinol Usage And Synthesis
| Chemical Properties | Off White Solid |
| Uses | 4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine is an inhibitor to study the specificity and kinetics of xanthine oxidase. It is also used as an anti-inflammatory agent via inhibition of xanthine oxidase. |
| Uses | Oxypurinol, an allopurinol metabolite, is used as an inhibitor to study the specificity and kinetics of of xanthine oxidase(s). Oxypurinol is also used as an anti-inflammatory agent via inhibition of xanthine oxidase. |
| Uses | A metabolite of Allopurinol. |
| Definition | ChEBI: A pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6. |
| Biological Activity | oxipurinol is a xanthine oxidoreductase inhibitor.xanthine oxidoreductase (xo), a complex molybdoflavoenzyme present in milk and many other tissues, has been studied for many years. xo is generally recognized as a critical enzyme in purine catabolism. |
| Biochem/physiol Actions | An allopurinol metabolite. |
| in vitro | allopurinol could be rapidly oxidized by xo to its active metabolite oxypurinol (both isosteres of hypoxanthine and xanthine, respectively), which also could inhibit xo. oxypurinol was identified as a noncompetitive inhibitor of xo; the formation of this compound was reported to be responsible for much of the pharmacological activity of allopurinol. moreover, both allopurinol and oxypurinol showed free radical scavenging effects in isolated hearts, and exerted cardioprotective effects despite no detectable xo activities [1]. |
| in vivo | animal study found that in the vasculature of hypercholesterolemic rabbits, oxypurinol treatment led to a decrease in vascular free radical production [1]. |
| references | [1] p. pacher, a. nivorozhkin and c. szabó. therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. pharmacological reviews 58(1), 87-114 (2006).
[2] day ro, graham gg, hicks m, mclachlan aj, stocker sl, williams km. clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. clin pharmacokinet. 2007;46(8):623-44. |
Oxipurinol Preparation Products And Raw materials
| Raw materials | Ethanol-->Ethyl acetate-->Diethyl ether-->Sodium-->Acetic anhydride-->Hydrazinium hydroxide solution-->Triethyl orthoformate-->Diethyl oxalate-->Sodium hypochlorite-->Sodium ethoxide-->Diethyl oxalacetate |
