Paraffin, liquid CAS 8012-95-1
Introduction：Basic information about Paraffin, liquid CAS 8012-95-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Paraffin, liquid Basic information
| Product Name: | Paraffin, liquid |
| Synonyms: | LIQUID PARAFFIN;LIQUID PETROLATUM;LIGHT WHITE MINERAL OIL, SULFURDEPLETED;LIGHT WHITE OIL;PARAFFIN OIL, FOR IR-SPECTROSCOPY;1 4-DIOXAN SPECTRANAL STABILIZED;PARAFFIN VISCID, EXTRA PURE, DAB, PH. EU R., B. P., PH. FRANC.;VASELINE OIL EXTRA PURE COSMETIC GRADE |
| CAS: | 8012-95-1 |
| MF: | unspecified |
| MW: | 0 |
| EINECS: | 232-384-2 |
| Product Categories: | Analytical Reagents;Analytical/Chromatography;Infrared (IR) Spectroscopy;IR Solvents;IR Spectroscopy Solvents;NMR;Solvent by Application;Solvents;Spectroscopy Solvents (IR;UV/Vis);Lipids and Related ProductsPharmacopoeia (USP);Pharmacopoeia A-Z;Core Bioreagents;Research Essentials;IR Spectroscopy;IR Spectroscopy Solvents;Spectroscopy;1 |
| Mol File: | Mol File |
Paraffin, liquid Chemical Properties
| Melting point | -24 °C (lit.) |
| Boiling point | 300 °C (lit.) |
| density | 0.827-0.890 g/mL at 20 °C |
| refractive index | n |
| Fp | >300°C |
| storage temp. | Store at room temperature. |
| solubility | Practically insoluble in ethanol (95%), glycerin, andwater; soluble in acetone, benzene, chloroform, carbon disulfide,ether, and petroleum ether. Miscible with volatile oils and fixedoils, with the exception of castor oil. |
| form | light oil |
| color | white |
| Specific Gravity | 0.870 (20/4℃) |
| Odor | Odorless |
| Water Solubility | Soluble in ether. Sparingly soluble in ethanol. Not miscible or difficult to mix in water. |
| Merck | 14,7023 |
| Exposure limits | ACGIH: TWA 5 mg/m3 OSHA: TWA 5 mg/m3 NIOSH: IDLH 2500 mg/m3; TWA 5 mg/m3; STEL 10 mg/m3 |
| Dielectric constant | 2.0（Ambient） |
| Cosmetics Ingredients Functions | SKIN CONDITIONING - EMOLLIENT SOLVENT ANTISTATIC SKIN PROTECTING FRAGRANCE HAIR CONDITIONING PERFUMING SKIN CONDITIONING - OCCLUSIVE |
| EPA Substance Registry System | Paraffin oils (8012-95-1) |
Safety Information
| Hazard Codes | Xi,N |
| Risk Statements | 36-51/53 |
| Safety Statements | 26-61 |
| OEB | B |
| OEL | TWA: 5 mg/m3, STEL: 10 mg/m3 |
| WGK Germany | 1 |
| RTECS | PY8030000 |
| Autoignition Temperature | 245°C |
| TSCA | TSCA listed |
| HS Code | 27122090 |
| Storage Class | 10 - Combustible liquids |
| Hazardous Substances Data | 8012-95-1(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: > 24gm/kg |
| IDLA | 2,500 mg/m3 |
| Description | Mineral oil mist is a colorless, oily liquid aero-sol dispersed in air with an odor like burned lubricating oil.The odor threshold is 1.0 ppm. Specific gravity (H2O:1)=0.865 at 60℃; Boiling point = 250- 360*C; Vaporpressure = <0.5 mmHg at 20℃; Flash point= 193℃;Autoignition temperature = 260- 371℃. HazardIdentification (based on NFPA-704 M Rating System):Health 0, Flammability 1, Reactivity 0. Insoluble in water. |
| Chemical Properties | Clear colorless oil |
| Chemical Properties | Mineral oil is a transparent, colorless, viscous oily liquid, withoutfluorescence in daylight. It is practically tasteless and odorless whencold, and has a faint odor of petroleum when heated. |
| Uses | Mineral oil is a lubricant and is used asa solvent for inks in the printing industry. |
| Uses | Paraffin Oils is a useful organic solvent for isolating the nucleus of the gian amphibian oocyte. |
| Uses | Laxative; pharmaceutic aid (solvent). |
| Definition | Liquid hydrocarbons from petroleum. |
| Production Methods | Mineral oil is obtained by distillation of petroleum. The lighterhydrocarbons are first removed by distillation and the residue isthen redistilled between 330–390°C. The distillate is chilled and thesolid fractions are removed by filtration. The filtrate is then furtherpurified and decolorized by high-pressure hydrogenation or sulfuricacid treatment; the purified filtrate is then filtered throughadsorbents. The liquid portion obtained is distilled and the portionboiling below 360°C is discarded. A suitable stabilizer may beadded to the mineral oil; |
| Brand name | Balneol(Solvay Pharmaceuticals); Neo-Cultol (Fisons); Nujol(Schering-Plough HealthCare). |
| General Description | Transparent colorless oily liquid. Practically tasteless and odorless, even when warmed. |
| Air & Water Reactions | Flammable. Insoluble in water. |
| Reactivity Profile | OIL. [MINERAL] may be incompatible with strong oxidizing agents like nitric acid. Charring may occur followed by ignition of unreacted oil and other nearby combustibles. In other settings, mostly unreactive. Not affected by aqueous solutions of acids, alkalis, most oxidizing agents, and most reducing agents. Burns exothermically when heated sufficiently or when ignited in the presence of air, oxygen or strong oxidizing agents. |
| Hazard | Inhalation of vapor or particulates can causeaspiration pneumonia. Combustible liquid. Upperrespiratory tract irritant. Questionable carcinogen. |
| Health Hazard | Highly refined mineral oil mistis of low toxicity. |
| Fire Hazard | PARAFFIN is combustible. |
| Pharmaceutical Applications | Mineral oil is used primarily as an excipient in topical pharmaceuticalformulations, where its emollient properties are exploited as aningredient in ointment bases. It is additionally used inoil-in-water emulsions,as a solvent, and as a lubricant incapsule and tablet formulations, and to a limited extent as a mold-release agent for cocoa butter suppositories. It has also been used inthe preparation of microspheres and as a vaccine adjunct. Therapeutically, mineral oil has been used as a laxative.It is indigestible and thus has limited absorption.Mineral oil is used in ophthalmic formulations for its lubricantproperties. It is also used in cosmetics and some food products. |
| Safety Profile | A human teratogen byinhalation that causes testicular tumors inthe fetus. Inhalation of vapor or particulatescan cause aspiration pneumonia. A skin andeye irritant. Highly purified food grades areof low toxicity. Questionable humancarcinogen producing gastrointestinaltumors. Slightly combustible liquid whenexposed to heat or flame. To fight fire, usedry chemical, CO2, foam. When heated todecomposition it emits acrid smoke andfumes. |
| Safety | Mineral oil is used as an excipient in a wide variety ofpharmaceutical formulations. It is also used incosmetics and in some food products. Therapeutically, mineral oil has been used in the treatment ofconstipation, as it acts as a lubricant and stool softener when takenorally. Daily doses of up to 45mL have been administered orally,while doses of up to 120mL have been used as an enema. However,excessive dosage of mineral oil, either orally or rectally, can result inanal seepage and irritation, and its oral use as a laxative is notconsidered desirable. Chronic oral consumption of mineral oil may impair the appetiteand interfere with the absorption of fat-soluble vitamins. Prolongeduse should be avoided. Mineral oil is absorbed to some extent whenemulsified and can lead to granulomatous reactions. Similarreactions also occur upon injection of the oil;injection mayalso cause vasospasm. The most serious adverse reaction to mineral oil is lipoidpneumonia caused by aspiration of the oil.Mineral oil canenter the bronchial tree without eliciting the cough reflex.Withthe reduction in the use of mineral oil in nasal formulations, theincidence of lipoid pneumonia has been greatly reduced. However,lipoid pneumonia has also been associated with the use of mineraloil-containing cosmetics and ophthalmic preparations.It isrecommended that products containing mineral oil not be used invery young children, the elderly, or persons with debilitatingillnesses. Given its widespread use in many topical products, mineral oilhas been associated with few instances of allergic reactions.The WHO has not specified an acceptable daily intake ofmineral oil given the low concentration consumed in foods. LD50 (mouse, oral): 22 g/kg |
| Potential Exposure | Tumorigen,Human Data; Primary Irritant. Mineral oil is used in cosmetics, pharmaceutical bases, food, and fiber production; ascarriers and bases; as a lubricating oil; and as a solvent forinks in the printing industry. Oil mist would be encounteredin quenching of hot metal parts and in metal machiningoperations. |
| First aid | If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility |
| storage | Mineral oil undergoes oxidation when exposed to heat and light.Oxidation begins with the formation of peroxides, exhibiting an‘induction period’. Under ordinary conditions, the induction periodmay take months or years. However, once a trace of peroxide isformed, further oxidation is autocatalytic and proceeds veryrapidly. Oxidation results in the formation of aldehydes andorganic acids, which impart taste and odor. Stabilizers may be added to retard oxidation; butylated hydroxyanisole, butylatedhydroxytoluene, and alpha tocopherol are the most commonly usedantioxidants. Mineral oil may be sterilized by dry heat. Mineral oil should be stored in an airtight container, protectedfrom light, in a cool, dry place. |
| Purification Methods | Treat the oil with fuming H2SO4 (care), then wash it with water and dilute aqueous NaOH, then percolate it through activated silica gel. Paraffin Wax. Melt the wax in the presence of NaOH, wash it with water until all of the base had been removed. The paraffin is allowed to solidify after each wash. Finally, 5g of paraffin is melted by heating it on a water-bath, then shaken for 20-30minutes with 100mL of boiling water and and dry the melt under vacuum. |
| Incompatibilities | Incompatible with strong oxidizing agents. |
| Toxics Screening Level | The initial threshold screening level (ITSL) for mineral oil (CAS# 8012-95-1) is 50 μg/m3 on an 8-hour averaging time. |
| Regulatory Status | GRAS listed. Accepted in the UK for use in certain foodapplications. Included in the FDA Inactive Ingredients Database(dental preparations; IV injections; ophthalmic preparations; oralcapsules and tablets; otic, topical, transdermal, and vaginalpreparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinalIngredients. |
Paraffin, liquid Preparation Products And Raw materials
| Raw materials | Paraffin wax-->POLY(1-GLYCEROL METHACRYLATE) |
| Preparation Products | 2-FLUORONAPHTHALENE-->N-Ethylmaleimide |
