Introduction：Basic information about Patchouli alcohol CAS 5986-55-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Patchouli alcohol Basic informationDescription Uses
| Product Name: | Patchouli alcohol |
| Synonyms: | 1,6-Methanonaphthalen-1(2H)-ol, octahydro-4,8a,9,9-tetramethyl-, [1R-(1α,4,4aα ,6,8aα)]-;C09705;4beta,4aalpha,6beta,8aalpha)]-ph;6-methanonaphthalen-1(2h)-ol,octahydro-4,8a,9,9-tetramethyl-[1theta-(1al;Patchoulanol;Patchoulic alcohol;Patchoulol;[1R-(1alpha,4beta,4aalpha,6beta,8aalpha)]-octahydro-4,8a,9,9-tetramethyl-1,6-methano-1(2H)-naphthol |
| CAS: | 5986-55-0 |
| MF: | C15H26O |
| MW: | 222.37 |
| EINECS: | 227-807-2 |
| Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Organics |
| Mol File: | 5986-55-0.mol |
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Patchouli alcohol Chemical Properties
| Melting point | 56°; mp (racemate) 39-40° (Danishevsky, Dumas); mp 46-47° (Mirrington, Schmalzl) |
| alpha | D20 -97.4° (c = 24 in chloroform) |
| Boiling point | bp8 140° |
| density | d420 1.0284 |
| vapor pressure | 0.14Pa at 24℃ |
| refractive index | nD65 1.5029 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Solid |
| pka | 15.23±0.70(Predicted) |
| color | White to Off-White |
| Odor | at 100.00 %. patchouli earthy camphor powdery |
| Odor Type | woody |
| Water Solubility | 41.8mg/L at 24℃ |
| Major Application | food and beverages |
| Cosmetics Ingredients Functions | PERFUMING |
| InChI | 1S/C15H26O/c1-10-5-8-15(16)13(2,3)11-6-7-14(15,4)12(10)9-11/h10-12,16H,5-9H2,1-4H3/t10-,11?,12?,14-,15?/m0/s1 |
| InChIKey | GGHMUJBZYLPWFD-DUNKBJDJSA-N |
| SMILES | CC1(C)[C@@H]2CC[C@]3(C)[C@@]1(O)CC[C@H](C)[C@@H]3C2 |
| LogP | 5.5 at 25℃ |
| NIST Chemistry Reference | Patchouli alcohol(5986-55-0) |
| EPA Substance Registry System | 1,6-Methanonaphthalen-1(2H)-ol, octahydro-4,8a,9,9-tetramethyl-, (1R,4S,4aS,6R,8aS)- (5986-55-0) |
Safety Information
| Safety Statements | 24/25 |
| WGK Germany | WGK 3 |
| TSCA | TSCA listed |
| HS Code | 29061990 |
| Storage Class | 11 - Combustible Solids |
Patchouli alcohol Usage And Synthesis
| Description | Herbal oils are of various types depending on herbs used to extract the oil. The most important bioactive constituents of plants are alkaloids, tannins, flavonoids, and phenolic compounds. Amongst popular oils, Patchouli oil extracted from Pogostemon cablin is known not just for its health benefits but also for its fragrance. Patchouli is a perennial herb and a fragrant plant that basically grows in the tropical region throughout the world. Though patchouli oil is known for its perfumery uses and there are other medicinal properties attached with patchouli oil. Patchouli oil’s growing demand can be understood as it can neither be replaced inorganically nor synthesized because of its complex molecular structure. Hence, the only alternative is to cultivate the plant extensively. The aim of the present paper is to review the importance of patchouli extractions in the treatment of diseases that may be useful for the applications of this medicinal plant in the treatment of diseases. |
| Uses | Patchouli alcohol is a fragrance ingredient used in decorative cosmetics, fine fragrances, shampoos, toilet soaps, non-cosmetic products such as household cleaners and detergents. Patchoulic alcohol is commonly used as an indicator for the quality assessment of dried P. cablin. It also used as daily dosage along with other herbs for treatment of asthma. |
| Chemical Properties | Derived from the dried aerial parts of the Patchouli plant |
| Uses | Patchouli Alcohol is a sesquiterpene extract which has been tested against insects and fungus, it is an antibacterial or insecticidal agent. |
| Definition | ChEBI: A carbotricyclic compound and sesquiterpenoid tertiary alcohol that is tricyclo[5.3.1.03,8]undecan-3-ol which is substituted at positions 2, 2, 6 and 8 by methyl groups (the 1R,3R,6S,7stereo>S,8S-diastereoisomer). |
| Flammability and Explosibility | Not classified |
| in vivo | Patchouli alcohol (5-20 mg/kg; oral administration; for 2 weeks) significantly protects the gastric mucosa from H. pylori-induced damage. Patchouli alcohol effectively attenuates oxidative stress by decreasing contents of intracellular ROS and MDA, and increasing levels of NP-SH, GSH/GSSG. Patchouli alcohol significantly attenuates the secretions of IL-1β, keratinocyte chemoattractant and IL-6[1]. | Animal Model: | Five- to six-week-old male C57BL/6 mice injected with H. pylori[1] | | Dosage: | 5, 10, and 20 mg/kg | | Administration: | Oral administration; for 2 weeks | | Result: | Effectively attenuated oxidative stress by decreasing contents of intracellular reactive oxygen species (ROS) and MDA, and increasing levels of non-protein sulfhydryl (NP-SH), catalase and glutathione (GSH)/glutathione disulphide (GSSG). |
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Patchouli alcohol Preparation Products And Raw materials
| Preparation Products | α-Patchoulene |
