Introduction：Basic information about Phlorizin dihydrate CAS 7061-54-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Phlorizin dihydrate Basic information
| Product Name: | Phlorizin dihydrate |
| Synonyms: | Phlorizin dihydrate 1-[2-(beta-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone dihydrate;1-[2,4-dihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]phenyl]-3-(4-hydroxyphenyl)-1-propanone dihydrate;2'-O-GLUCOSYL-4',6',4-TRIHYDROXYDIHYDROCHALCONE;1-[2-(beta-d-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone dihydrate;TIMTEC-BB SBB005924;PHLORETIN-2'-BETA-D-GLUCOSIDE;PHLORIDZIN;phloridzin from apple wood |
| CAS: | 7061-54-3 |
| MF: | C21H26O11 |
| MW: | 454.43 |
| EINECS: | 628-113-6 |
| Product Categories: | Natural Plant Extract |
| Mol File: | 7061-54-3.mol |
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Phlorizin dihydrate Chemical Properties
| Melting point | 113-114 °C(lit.) |
| alpha | -52 º (c=3, EtOH) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Solid |
| color | White to off-white |
| biological source | apple wood |
| Optical Rotation | [α]20/D 52°, c = 3 in ethanol |
| BRN | 66621 |
| InChIKey | XQWBNXSENPTIDY-YXMARJSJSA-N |
| SMILES | O.O.OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc3ccc(O)cc3)[C@H](O)[C@@H](O)[C@@H]1O |
| CAS DataBase Reference | 7061-54-3(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | UC2080000 |
| F | 3-10-23 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
Phlorizin dihydrate Usage And Synthesis
| Chemical Properties | White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from crabapple leaves and apple tree branches and leaves. |
| Uses | Phloridzin dihydrate has been used as:
- a Na+-glucose cotransport inhibitor to test its effect in lowering blood glucose
- a hexose carrier inhibitor to prevent glucose derivative 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) uptake in sycamore cells
- a non-specific sodium-glucose co-transporter 2 (SGLT2) inhibitor in embryonic cardiomyocyte cell line H9C2 to investigate its protective effect on Dox-induced cytotoxicity
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| Biochem/physiol Actions | Phloridzin is a glycoside present in the leaves and bark of apple. It is also present in peel and pulp of the apple fruit. Phloridzin belongs to the dihydrochalcones class of compounds. Lactase catabolizes phloridzin to phloretin and glucose in small intestine epithelial cells. Phloridzin is an antidiabetic agent and is equally bioavailable as phloretin. |
| target | NO | PGE | NOS | COX |
Phlorizin dihydrate Preparation Products And Raw materials
