Introduction：Basic information about Pranoprofen CAS 52549-17-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Pranoprofen Basic information
| Product Name: | Pranoprofen |
| Synonyms: | PRANOPROFEN;(RS)-Pranoprofen;5H-[1]Benzopyrano[2,3-b]pyridine-7-acetic acid, a-methyl- (9CI);a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-ylacetic acid;dl-Pranoprofen;Niflan;Y 8004;pyranoprofen |
| CAS: | 52549-17-4 |
| MF: | C15H13NO3 |
| MW: | 255.27 |
| EINECS: | 682-035-7 |
| Product Categories: | NIFLAN;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;>97%,BR;52549-17-4 |
| Mol File: | 52549-17-4.mol |
|
Pranoprofen Chemical Properties
| Melting point | 182-183° |
| Boiling point | 398.5°C (rough estimate) |
| density | 1.1654 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | powder |
| pka | 4.27±0.10(Predicted) |
| color | white to beige |
| InChI | InChI=1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18) |
| InChIKey | TVQZAMVBTVNYLA-UHFFFAOYSA-N |
| SMILES | C(C1C=CC2OC3=NC=CC=C3CC=2C=1)(C)C(=O)O |
| CAS DataBase Reference | 52549-17-4(CAS DataBase Reference) |
Safety Information
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 1 |
| RTECS | DJ3100950 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
| Toxicity | LD50 in male mice, rats (mg/kg): 447.3, 87.3 orally (Edanaga) |
Pranoprofen Usage And Synthesis
| Chemical Properties | Off-White Solid |
| Originator | Niflan, Yoshitomi ,Japan ,1981 |
| Uses | Pranoprofen is an anti-inflammatory used in ophthalmology. |
| Definition | ChEBI: Pranoprofen is a pyridochromene. |
| Manufacturing Process | A mixture of 100 g of ethyl 2-cyano-2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionate, 500 ml of glacial acetic acid and 200 g of concentrated hydrochloric acid is refluxed for 48 hours. The reaction mixture is concentrated, and the residue is dissolved in hot water. The solution is adjusted to pH 2 to 3 by addition of 10% sodium hydroxide. The resulting crystalline precipitate is washed thoroughly with water, and recrystallized from aqueous dioxane to give 74 g of 2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionic acid as white crystals melting at 183°C to 183.5°C. |
| Therapeutic Function | Analgesic, Antiinflammatory |
| General Description | Pranoprofen is an arylalkanoic acid and a non-steroidal anti-inflammatory drug. |
| Biochem/physiol Actions | Pranoprofen is used in eyes to treat chronic allergic conjunctivitis. It is also used as an anti-inflammatory and analgesic drug after strabismus surgery. |
Pranoprofen Preparation Products And Raw materials
| Raw materials | Hydrochloric acid |
