Introduction：Basic information about Prasugrel Hydrochloride CAS 389574-19-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Prasugrel Hydrochloride Basic information
| Product Name: | Prasugrel Hydrochloride |
| Synonyms: | PRASUGREL HYDROCHLORIDE;2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone hydrochloride;Unii-G89jq59I13;Prasugrenhydrochloride;Prasugrel HCl;5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-2H,4H,5H,6H,7H,7aH-thieno[3,2-c]pyridin-2-one;acetic acid [5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-2-yl] ester;Prasugrel(Discontinued) |
| CAS: | 389574-19-0 |
| MF: | C20H20FNO3S.ClH |
| MW: | 409.907 |
| EINECS: | 627-126-4 |
| Product Categories: | API |
| Mol File: | 389574-19-0.mol |
|
Prasugrel Hydrochloride Chemical Properties
| Melting point | >173?C (dec.) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| color | White to Pale Brown |
| Major Application | pharmaceutical |
| InChI | InChI=1S/C20H20FNO3S.ClH/c1-12(23)25-18-10-14-11-22(9-8-17(14)26-18)19(20(24)13-6-7-13)15-4-2-3-5-16(15)21;/h2-5,10,13,19H,6-9,11H2,1H3;1H |
| InChIKey | JALHGCPDPSNJNY-UHFFFAOYSA-N |
| SMILES | N1(CCC2SC(OC(C)=O)=CC=2C1)C(C1C=CC=CC=1F)C(=O)C1CC1.Cl |
Safety Information
| WGK Germany | WGK 2 |
| HS Code | 2934990002 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Chronic 2 |
Prasugrel Hydrochloride Usage And Synthesis
| Description | Prasugrel hydrochloride (PCR 4099 hydrochloride), a thienopyridine and proagent, inhibits platelet function. Prasugrel hydrochloride is an orally active and potent P2Y12 receptor antagonist and inhibits ADP-induced platelet aggregation. |
| Chemical Properties | White to Off-White Solid |
| Uses | A novel antiplatelet agent; it is a third-generation thienopyridine. Antiplatelet agent Prasugrel showed greater platelet inhibition and decreased incidence of ischemic events than Clopidogrel but may induce increased incidence of bleeding in patient with acute coronary syndrome |
| in vivo | In rat platelets, Prasugrel hydrochloride active metabolite inhibits in vitro platelet aggregation induced by adenosine ADP (10μM) with an IC50 value of 1.8 μM.Prasugrel hydrochloride acts faster and is significantly more potent than Clopidogrel in vivo. Prasugrel hydrochloride is an inactive prodrug that requires metabolic processing in vivo to generate the active antiplatelet metabolite. Prasugrel hydrochloride is rapidly absorbed from the gut. After oral administration of standard-loading doses of 60 mg, maximum plasma levels of the active metabolite are achieved within 1 h, effective, maximum inhibition of platelet aggregation at 1-2 h. |
| IC 50 | P2Y12 Receptor |
Prasugrel Hydrochloride Preparation Products And Raw materials
