Pro-xylane CAS 439685-79-7

Introduction：Basic information about Pro-xylane CAS 439685-79-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Pro-xylane Basic information

• Product Name: Pro-xylane
• Synonyms: (2S,3R,4S,5R)-2-(2-hydroxypropyl)oxane-3,4,5-triol;Nano liposomal hydroxypripyl tetrahydropyrantriol;Retinol Pro+Pro-xylane;Pro-Xylane,Puri-Xylane;HYDROXYPROPYL TETRAHYDROPYRANTRIOL;Puri-Xylane;Nano Liposomal HYDROXYPROPYL TETRAHYDROPYRANTRIOL;Tetrahydropyrantriol
• CAS: 439685-79-7
• MF: C8H16O5
• MW: 192.21
• EINECS: 456-880-5
• Product Categories: API;439685-79-7;1
• Mol File: 439685-79-7.mol

Pro-xylane Chemical Properties

• Boiling point: 376.0±42.0 °C(Predicted)
• density: 1.368±0.06 g/cm3(Predicted)
• vapor pressure: 0Pa at 25℃
• storage temp.: Store at -20°C
• solubility: Water: 250 mg/mL (1300.66 mM); DMSO: ≥ 83.33 mg/mL (433.54 mM)
• form: Liquid
• pka: 13.55±0.70(Predicted)
• color: Colorless to light yellow
• Cosmetics Ingredients Functions: SKIN CONDITIONING
• InChI: InChI=1/C8H16O5/c1-4(9)2-6-8(12)7(11)5(10)3-13-6/h4-12H,2-3H2,1H3/t4?,5-,6+,7+,8+/s3
• InChIKey: KOGFZZYPPGQZFZ-ZXWVZLFTNA-N
• SMILES: C([C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O)C(O)C |&1:1,4,6,8,r|
• LogP: -2.07

Pro-xylane Usage And Synthesis

cosmetic ingredient

Pro-Xylane is a cosmetic ingredient used mainly as an anti-ageing agent in skin creams. Produced by Chimex, its chemical structure is derived from the xylose, a natural component of glycosaminoglycans and of hemicellulose. Pro-Xylane is produced in a two-steps process: 1) The reaction of xylose and acetylacetone in water, then 2) the hydrogenation of the intermediate.

Physical Form

Powder

Cosmetics Application

Pro-Xylane is a biochemical which induces neo-synthesis of matrix proteins. It is a biologically active C-glycoside in aqueous media, acts as an activator of glycosaminoglycans (GAGs) biosynthesis. Pro-xylane is the first example of 'Green' chemical used in cosmetic.
Pro-Xylane is an ingredient originally developed by Lancome in 2006. According to research, it is a sugar-protein hybrid made from xylose, a sugar found abundantly in beech trees and known to stimulate the production of glycoaminoglycans (GAGs), molecules responsible for defending the skin against water loss.

function

Pro-Xylane is a sugar-molecule derived from the beech wood tree utilizing green chemistry. It functions, in vitro, by stimulating the production of proteoglycans, a water-absorbing molecule in human reconstructed skin.

Description

Pro-xylane (PX) is a cosmetic ingredient used for skin conditioning and is widely used in anti-aging product research. It is considered to be an optimal activator for the biosynthesis of glycosaminoglycans (GAGs) sulphate and can be used to prepare a novel bioactive c-glycoside compound, which is a "green" chemical. In addition, Pro-xylane has been shown to enhance the blue colour of anthocyanins (ACNs), with ACNs-PX showing a colour close to Oxford blue, a surface height of 2.13 ± 0.14 nm and a slight increase in stability^[1-2].

Chemical Properties

Pro-xylane is an organic compound with the appearance of a pale yellow to off-white powder or a colourless viscous liquid, stored in a cool dry place, and has been used in experiments related to the basic science of aging.

Uses

Pro-Xylane is a sugar-molecule derived from the beech wood tree utilizing green chemistry. It functions, in vitro, by stimulating the production of proteoglycans, a water-absorbing molecule in human reconstructed skin. Higher levels of proteoglycans within the reconstructed skin’s extracellular matrix correlate to increase skin-elasticity and firmness. In cosmetics, pro-xylane products are frequently incorporated into anti-aging lotions and creams to counterbalance signs of aging (i.e., fine lines and wrinkles).

Mechanism of action

Pro-Xylane enters the skin and stimulates the part that produces and builds the extracellular matrix (a gel-like network of proteins and sugars that act as a scaffold and shock absorber between cells) called proteoglycans.These molecules absorb water and make the matrix more gel-like, increasing the firmness of the cells and increasing the firmness of the skin.It can also serve as a highway to guide supplemental molecules (such as growing proteins) to cells.

References

[1] ALEXANDRE CAVEZZA . Synthesis of Pro-XylaneTM: A new biologically active C-glycoside in aqueous media[J]. Bioorganic & Medicinal Chemistry Letters, 2009. DOI:10.1016/j.bmcl.2008.12.037.
[2] KAI DENG. Improved Stability of Blue Colour of Anthocyanins from Lycium ruthenicum Murr. Based on Copigmentation.[J]. Molecules, 2022. DOI:10.3390/molecules27186089.