Introduction：Basic information about LY 294002 Hydrochloride CAS 154447-36-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
LY 294002 Hydrochloride Basic informationBackground
| Product Name: | LY 294002 Hydrochloride |
| Synonyms: | LY 294002;LY 294002 HYDROCHLORIDE;2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE;2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE;CS-1859;LY294002 (HCl Salt) |
| CAS: | 154447-36-6 |
| MF: | C19H17NO3 |
| MW: | 307.34 |
| EINECS: | 1312995-182-4 |
| Product Categories: | PI3K/Akt Signaling;Inhibitors;Inhibitor;Anti-cancer&immunity;PI3K/Akt/mTOR;Akt;Lipid signaling;Signalling;Cell Cycle Regulation;apis;mTOR;PI3K |
| Mol File: | 154447-36-6.mol |
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LY 294002 Hydrochloride Chemical Properties
| Melting point | 183-185℃ |
| Boiling point | 494.6±45.0 °C(Predicted) |
| density | 1.266 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: >5 mg/mL |
| form | solid |
| pka | 0.55±0.20(Predicted) |
| color | white to off-white |
| Water Solubility | Soluble in DMSO at 5mg/ml. Insoluble in water |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. |
| InChI | InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 |
| InChIKey | CZQHHVNHHHRRDU-UHFFFAOYSA-N |
| SMILES | C1(N2CCOCC2)OC2=C(C3=CC=CC=C3)C=CC=C2C(=O)C=1 |
| CAS DataBase Reference | 154447-36-6 |
Safety Information
| Safety Statements | 24-25 |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Storage Class | 10 - Combustible liquids |
LY 294002 Hydrochloride Usage And Synthesis
| Description | LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM. |
| Uses | LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590). |
| Uses | A potent blocker of PI 3-kinase/Akt signaling. |
| Uses | LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice. |
| Definition | ChEBI: LY294002 is a chromone substituted with a phenyl group at position 8 and a morpholine group at position 2. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, an autophagy inhibitor and a geroprotector. It is a member of chromones, a member of morpholines and an organochlorine compound. |
| Biological Activity | A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo . |
| target | p110α |
| Background | LY294002 was shown to act in vivo as a highly selective inhibitor of phosphatidylinositol 3 kinase. When used at a concentration of 50 μM, it specifically abolished PI3 kinase activity but did not inhibit other lipid and protein kinases such as PI4 kinase, PKC, MAP kinase or c-Src. LY294002 is soluble in DMSO or ethanol. For use with in vitro or cell-based assays, it may be diluted into aqueous buffers to yield the desired concentrations. |
| References | [1] C. VLAHOS. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).[J]. The Journal of Biological Chemistry, 1994, 93 1: 5241-5248. DOI:10.1016/s0021-9258(17)37680-9.
[2] SEVERINE I GHARBI. Exploring the specificity of the PI3K family inhibitor LY294002.[J]. ACS Applied Energy Materials, 2007: 15-21. DOI:10.1042/BJ20061489.
[3] SANCHEZMARGALET V. Role of Phosphatidylinositol-3-Kinase in Insulin Receptor Signaling: Studies with Inhibitor, LY294002[J]. Biochemical and biophysical research communications, 1994, 204 2: Pages 446-452. DOI:10.1006/bbrc.1994.2480. |
LY 294002 Hydrochloride Preparation Products And Raw materials
| Raw materials | 4H-1-Benzopyran-4-one, 8-hydroxy-2-(4-morpholinyl)--->1-(2-hydroxybiphenyl-3-yl)-3-morpholinopropane-1,3-dione-->N-Acetylmorpholine-->Trifluoro-methanesulfonic acid 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl ester-->methyl 2-hydroxy-3-phenyl-benzoate-->methyl 2,3-dihydroxybenzoate-->Methyl 3-methoxysalicylate-->2,3-Dihydroxybenzoic acid-->3-Methoxysalicylic acid-->Phenylboronic acid |
