CAS 478-08-0|Lucidin

Introduction：Basic information about CAS 478-08-0|Lucidin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Lucidin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Synonyms

Common Name	Lucidin
CAS Number	478-08-0	Molecular Weight	270.237
Density	1.6±0.1 g/cm3	Boiling Point	585.0±29.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₀O₅	Melting Point	330ºC
MSDS	/	Flash Point	321.6±20.8 °C

Names

Name	1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione
Synonym	More Synonyms

Lucidin BiologicalActivity

Description	Lucidin (NSC 30546) is a natural component of Rubia tinctorum L. lucidin is mutagenic in bacteria and mammalian cells.IC50 Value:Target: in vitro: Lucidin was mutagenic in five Salmonella typhimurium strains without metabolic activation, but the mutagenicity was increased after addition of rat liver S9 mix. In V79 cells, lucidin was mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus and active at inducing DNA single-strand breaks and DNA-protein cross-links as assayed by the alkaline elution method. Lucidin also induced DNA repair synthesis in primary rat hepatocytes and transformed C3H/M2-mouse fibroblasts in culture [1]. HPLC analysis of 32P-labelled DNA adducts revealed a peak co-migrating with an adduct obtained after in vitro treatment of deoxyguanosine-3'-phosphate with lucidin [2].in vivo: Dose-dependent increases in benign and malignant tumour formation were observed in the liver and kidneys of treated animals. 32P-post-labelling analysis showed an increase in the overall level of DNA adducts observed in the liver, kidney and colon of rats treated with 10% madder root in the diet for 2 weeks [2].Toxicity: lucidin is mutagenic in bacteria and mammalian cells [2].Clinical trial:
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>CancerNatural Products >>Others
References	[1]. Westendorf J, et al. The genotoxicity of lucidin, a natural component of Rubia tinctorum L., and lucidinethylether, a component of ethanolic Rubia extracts. Cell Biol Toxicol. 1988 Jun;4(2):225-39. [2]. Westendorf J, et al. Carcinogenicity and DNA adduct formation observed in ACI rats after long-term treatment with madder root, Rubia tinctorum L. Carcinogenesis. 1998 Dec;19(12):2163-8.

Description

Lucidin (NSC 30546) is a natural component of Rubia tinctorum L. lucidin is mutagenic in bacteria and mammalian cells.IC50 Value:Target: in vitro: Lucidin was mutagenic in five Salmonella typhimurium strains without metabolic activation, but the mutagenicity was increased after addition of rat liver S9 mix. In V79 cells, lucidin was mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus and active at inducing DNA single-strand breaks and DNA-protein cross-links as assayed by the alkaline elution method. Lucidin also induced DNA repair synthesis in primary rat hepatocytes and transformed C3H/M2-mouse fibroblasts in culture [1]. HPLC analysis of 32P-labelled DNA adducts revealed a peak co-migrating with an adduct obtained after in vitro treatment of deoxyguanosine-3'-phosphate with lucidin [2].in vivo: Dose-dependent increases in benign and malignant tumour formation were observed in the liver and kidneys of treated animals. 32P-post-labelling analysis showed an increase in the overall level of DNA adducts observed in the liver, kidney and colon of rats treated with 10% madder root in the diet for 2 weeks [2].Toxicity: lucidin is mutagenic in bacteria and mammalian cells [2].Clinical trial:

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>CancerNatural Products >>Others

References

[1]. Westendorf J, et al. The genotoxicity of lucidin, a natural component of Rubia tinctorum L., and lucidinethylether, a component of ethanolic Rubia extracts. Cell Biol Toxicol. 1988 Jun;4(2):225-39.

[2]. Westendorf J, et al. Carcinogenicity and DNA adduct formation observed in ACI rats after long-term treatment with madder root, Rubia tinctorum L. Carcinogenesis. 1998 Dec;19(12):2163-8.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	585.0±29.0 °C at 760 mmHg
Melting Point	330ºC
Molecular Formula	C₁₅H₁₀O₅
Molecular Weight	270.237
Flash Point	321.6±20.8 °C
Exact Mass	270.052826
PSA	94.83000
LogP	2.79
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.746
InChIKey	AMIDUPFSOUCLQB-UHFFFAOYSA-N
SMILES	O=C1c2ccccc2C(=O)c2c1cc(O)c(CO)c2O
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB6712000

CHEMICAL NAME :: Anthraquinone, 1,3-dihydroxy-2-hydroxymethyl-

CAS REGISTRY NUMBER :: 478-08-0

BEILSTEIN REFERENCE NO. :: 1888954

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H10-O5

MOLECULAR WEIGHT :: 270.25

WISWESSER LINE NOTATION :: L C666 BV IVJ DQ E1Q FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg/4D (Continuous)

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1265,1991

Synonyms

Henine

1,3-dihydroxy-2-hydroxymethyl-9,10-anthraquinone

1,3-dihydroxy-2-hydroxymethyl-9,10-anthracenedione

1,3-Dihydroxy-2-(hydroxymethyl)-9,10-anthraquinone

1,3-dihydroxy-2-hydroxymethyl-anthraquinone

Lucidin (quinone)

2-carbinol-1,3-dihydroxyanthraquinone

Lucidin

9,10-Anthracenedione, 1,3-dihydroxy-2-(hydroxymethyl)-

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