CAS 473278-54-5|2′-O-(2-Methoxyethyl)guanosine

Introduction：Basic information about CAS 473278-54-5|2′-O-(2-Methoxyethyl)guanosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 2′-O-(2-Methoxyethyl)guanosine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	2′-O-(2-Methoxyethyl)guanosine
CAS Number	473278-54-5	Molecular Weight	341.32000
Density	1.811g/cm3	Boiling Point	/
Molecular Formula	C₁₃H₁₉N₅O₆	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	2'-O-(2-Methoxyethyl)-guanosine
Synonym	More Synonyms

2′-O-(2-Methoxyethyl)guanosine BiologicalActivity

Description	2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA[1][2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. McPherson AK, et, al. An Improved Process for the Manufacture of 5′-O-(4,4′-Dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine. Org. Process Res. Dev. 2020, 24, 11, 2583-2590. [2]. Saleh AF, et, al. 2'-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells. Toxicol Sci. 2018 May 1;163(1):70-78.

Description

2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA[1][2].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. McPherson AK, et, al. An Improved Process for the Manufacture of 5′-O-(4,4′-Dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine. Org. Process Res. Dev. 2020, 24, 11, 2583-2590.

[2]. Saleh AF, et, al. 2'-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells. Toxicol Sci. 2018 May 1;163(1):70-78.

Chemical & Physical Properties

Density	1.811g/cm3
Molecular Formula	C₁₃H₁₉N₅O₆
Molecular Weight	341.32000
Exact Mass	341.13400
PSA	157.74000
Index of Refraction	1.745
InChIKey	DLLBJSLIKOKFHE-WOUKDFQISA-N
SMILES	COCCOC1C(O)C(CO)OC1n1cnc2c(=O)[nH]c(N)nc21

Safety Information

Hazard Codes	Xi
HS Code	2909199090

Customs

HS Code	2909199090
Summary	2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Synonyms

2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-3H-purin-6-one

2'-O-(2-Methoxyethyl)guanosine

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