Introduction：Basic information about CAS 25514-31-2|Bruceine A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bruceine A |
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| CAS Number | 25514-31-2 | Molecular Weight | 522.542 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 712.6±60.0 °C at 760 mmHg |
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| Molecular Formula | C26H34O11 | Melting Point | / |
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| MSDS | / | Flash Point | 237.1±26.4 °C |
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Names
| Name | brucein a |
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| Synonym | More Synonyms |
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Bruceine A BiologicalActivity
| Description | Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.IC50 value:Target: Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>InfectionNatural Products >>Others |
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| References | [1]. Nakao R, et al. Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis. J Vet Med Sci. 2009 Jan;71(1):33-41. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 712.6±60.0 °C at 760 mmHg |
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| Molecular Formula | C26H34O11 |
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| Molecular Weight | 522.542 |
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| Flash Point | 237.1±26.4 °C |
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| Exact Mass | 522.210083 |
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| PSA | 165.89000 |
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| LogP | 1.80 |
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| Vapour Pressure | 0.0±5.2 mmHg at 25°C |
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| Index of Refraction | 1.596 |
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| InChIKey | LPZSTPCYWWRQFU-VILODJCFSA-N |
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| SMILES | COC(=O)C12OCC34C(CC5C(C)=C(O)C(=O)CC5(C)C3C(O)C1O)OC(=O)C(OC(=O)CC(C)C)C24 |
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| Storage condition | -20°C |
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Synonyms
| Bruceine A |
| BRUCEIN A |
| Methyl (11β,12α,13β,15β)-3,11,12-trihydroxy-15-[(3-methylbutanoyl)oxy]-2,16-dioxo-13,20-epoxypicras-3-en-21-oate |
| Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11β,12α,13β,15β)- |
| Isobruceine A |
| 22,23-dihydrobrusatol |
