CAS 454-29-5|DL-Homocysteine
Introduction：Basic information about CAS 454-29-5|DL-Homocysteine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DL-Homocysteine | ||
|---|---|---|---|
| CAS Number | 454-29-5 | Molecular Weight | 135.185 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 299.7±35.0 °C at 760 mmHg |
| Molecular Formula | C4H9NO2S | Melting Point | 232-233 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 135.0±25.9 °C |
Names
| Name | DL-Homocysteine |
|---|---|
| Synonym | More Synonyms |
DL-Homocysteine BiologicalActivity
| Description | DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. |
|---|---|
| Related Catalog | Natural Products >>OthersResearch Areas >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | DL-Homocysteine (0.1-0.5 mM) significantly enhances kynurenic acid (KYNA) production in rat cortical slices, and diministes the production of at 3.0, 5.0, and 10.0 mM, with the estimated IC50 of 6.4 (5.5-7.5) mM. DL-Homocysteine dose-dependently inhibits kynurenine aminotransferases I (KATI) activity at concentrations ≥0.2 mM, with an IC50 of 0.566 (0.442-0.724) mM, and the activity of KAT II with IC50 value of 8.046 (5.804-11.154) mM[1]. |
| In Vivo | DL-Homocysteine (1.3 mmol/kg, i.p.) increases KYNA content (pmol/g tissue) from 8.47 ± 1.57 to 13.04 ± 2.86 and 11.4 ± 1.72 in cortex, and from 4.11 ± 1.54 to 10.02 ± 3.08 in rat hippocampus[1]. |
| References | [1]. DL-Homocysteine, et al. Dual effect of DL-homocysteine and S-adenosylhomocysteine on brain synthesis of the glutamate receptor antagonist, kynurenic acid. J Neurosci Res. 2005 Feb 1;79(3):375-82. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 299.7±35.0 °C at 760 mmHg |
| Melting Point | 232-233 °C(lit.) |
| Molecular Formula | C4H9NO2S |
| Molecular Weight | 135.185 |
| Flash Point | 135.0±25.9 °C |
| Exact Mass | 135.035400 |
| PSA | 102.12000 |
| LogP | 0.22 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.538 |
| InChIKey | FFFHZYDWPBMWHY-UHFFFAOYSA-N |
| SMILES | NC(CCS)C(=O)O |
| Storage condition | 2-8°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 770 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Phage inhibition capacity
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 125 mg/L
- REFERENCE :
- APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For publisher information, see AEMIDF. Volume(issue)/page/year: 12,234,1964
- TYPE OF TEST :
- Phage inhibition capacity
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 125 mg/L
- REFERENCE :
- APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For publisher information, see AEMIDF. Volume(issue)/page/year: 12,234,1964
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | C |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | MT0175000 |
| HS Code | 2930909090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles182
More Articles| Activation of AMP-activated protein kinase protects against homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by regulating the expressions of NADPH oxidase 1 (Nox1) and Nox2. Bone 77 , 135-41, (2015) Elevated plasma homocysteine (Hcy) level is associated with the risk of osteoporotic fracture. While Hcy increases oxidative stress, AMP-activated protein kinase (AMPK) activation ameliorates it. This... | |
| Protective effect of sulfurous water in peripheral blood mononuclear cells of Alzheimer's disease patients. Life Sci. 132 , 61-7, (2015) One of the main features of sulfurous water (SW) is the presence of hydrogen sulfide (H2S), which confers its antioxidant activity. Since oxidative stress plays an important role in Alzheimer's diseas... | |
| Sulfur amino acid metabolism in Zucker diabetic fatty rats. Biochem. Pharmacol. 96 , 256-66, (2015) The present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocyste... |
Synonyms
| DL-HoMocysteine |
| DL-2-amino-4-mercapto-Butyric acid |
| D-L-homocysteine |
| usafb-12 |
| Butyric acid, 2-amino-4-mercapto- |
| DL-2-Amino-4-mercaptobutyric acid |
| Butyric acid, 2-amino-4-mercapto-, DL- |
| 2-Amino-4-mercaptobutyric acid |
| D,L-Homocysteine |
| 2-Amino-4-mercaptobutanoic acid |
| HOMOCYSTEINE,DL |
| 2-AMINO-4-MERCAPTOBUYRIC ACID |
| 1-carboxy-3-mercaptopropylamine |
| Butanoic acid, 2-amino-4-mercapto- |
| 2-amino-4-mercapto-DL-Butyric acid |
| 2-amino-4-sulfanylbutanoic acid |
| Homocysteine (VAN) |
| TOTALHOMOCYSTEINE |
| H-DL-Hcys-OH |
| 2-Amino-4-Mercapto-Butyric Acid |
| EINECS 207-222-9 |
| homocystine |
| (±)-Homocysteine |
| 2-amino-4-mercapto-Butanoic acid |
| UNII:S7IJP4A89K |
| MFCD00004898 |
| Homocysteine |
| 2-thioethylglycine |
| Butyric acid, 2-amino-4-mercapto-, DL- (9CI) |
