CAS 92-54-6|1-Phenylpiperazine
Introduction：Basic information about CAS 92-54-6|1-Phenylpiperazine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-Phenylpiperazine | ||
|---|---|---|---|
| CAS Number | 92-54-6 | Molecular Weight | 162.232 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 287.2±15.0 °C at 760 mmHg |
| Molecular Formula | C10H14N2 | Melting Point | 18.8 °C |
| MSDS | ChineseUSA | Flash Point | 138.3±11.4 °C |
| Symbol | GHS05, GHS06 | Signal Word | Danger |
Names
| Name | 1-Phenylpiperazine |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 287.2±15.0 °C at 760 mmHg |
| Melting Point | 18.8 °C |
| Molecular Formula | C10H14N2 |
| Molecular Weight | 162.232 |
| Flash Point | 138.3±11.4 °C |
| Exact Mass | 162.115692 |
| PSA | 15.27000 |
| LogP | 1.11 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.544 |
| InChIKey | YZTJYBJCZXZGCT-UHFFFAOYSA-N |
| SMILES | c1ccc(N2CCNCC2)cc1 |
| Storage condition | Store in dark! |
| Water Solubility | Insoluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 140 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- DNA damage
MUTATION DATA - TYPE OF TEST :
- Micronucleus test
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 900 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 282,99,1992
- TYPE OF TEST :
- Micronucleus test
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 900 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 282,99,1992
Safety Information
| Symbol | GHS05, GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311-H314 |
| Precautionary Statements | Missing Phrase - N15.00950417-P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338 |
| Personal Protective Equipment | Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | T:Toxic; |
| Risk Phrases | R22;R24;R34 |
| Safety Phrases | S26-S36/37/39-S45-S28A |
| RIDADR | UN 2922 8/PG 2 |
| WGK Germany | 3 |
| RTECS | TM2625000 |
| Packaging Group | II |
| Hazard Class | 6.1 |
| HS Code | 29335995 |
Customs
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles26
More Articles| Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16). J. Med. Chem. 53(6) , 2510-20, (2010) Modification of the partial dopamine type 2 receptor (D(2)) agonist 3-(1-benzylpiperidin-4-yl)phenol (9a) generated a series of novel functional D(2) antagonists with fast-off kinetic properties. A re... | |
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. J. Med. Chem. 52(15) , 4923-35, (2009) Assembling phenylpiperazines with 7a-azaindole via different spacer elements, we developed subtype selective dopamine receptor ligands of types 1a,c, 2a, and 3a preferentially interacting with D4, D2,... | |
| Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography-mass spectrometry. J. Chromatogr. A. 1217(40) , 6274-80, (2010) A simple and sensitive procedure, using p-tolylpiperazine (pTP) as internal standard (IS), has been developed and validated for the qualitative and quantitative analysis of 1-(3-trifuoromethylphenyl)p... |
Synonyms
| phenyl piperazine |
| MFCD00005957 |
| 1-phenyl-piperazine |
| 4-Phenylpiperazine |
| Phenylpiperazine |
| 1-Fenylpiperazin |
| 1-PHENYLPIPERAZINE |
| 1-fenylpiperazine |
| N-PHENYLPIPERAZINE |
| 1-PHENYLPIPERAINE |
| EINECS 202-165-6 |
| 4-Ph-piperazine |
| Piperazine, 1-phenyl- |
