Introduction：Basic information about CAS 98603-84-0|Sialyl-Lewis X, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sialyl-Lewis X |
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| CAS Number | 98603-84-0 | Molecular Weight | 820.74400 |
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| Density | 1.66g/cm3 | Boiling Point | 1285.8ºC at 760mmHg |
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| Molecular Formula | C31H52N2O23 | Melting Point | / |
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| MSDS | USA | Flash Point | 731.4ºC |
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Names
| Name | sialyl lewis x |
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| Synonym | More Synonyms |
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Sialyl-Lewis X BiologicalActivity
| Description | Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation[2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vitro | Sialyl-Lewis X is a high-affinity ligand of CD62, Antibodies [mAb CSLEX (IgM; anti-sLeX)] to sLeX inhibit CD62-mediated binding of HL-60 cells to activated platelets[1]. Liposomes containing glycolipids with the sLeX structure prevents adhesion of HL-60 cells and human neutrophils. HL-60 cell adhesion is partially inhibited (50%) by liposomes containing Lex at 5 μg/ml. However, sLeX liposomes give maximal inhibition at only 1 ug/ml. sLeX liposomes inhibits adhesion with a 10-fold higher affinity than Lex liposomes[1]. CD62 binding of neutrophils to activated platelets is inhibited a soluble human milk oligosaccharide that contains the LeX structure. the sLeX sugar is a 30-fold more potent inhibitor than the nonsialylated Lex sugar, which requires 2 μg/ml and 54 μg/ml to achieve 50% inhibition of neutrophil adhesion, respectively[1]. |
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| References | [1]. M J Polley, et al. CD62 and Endothelial Cell-Leukocyte Adhesion Molecule 1 (ELAM-1) Recognize the Same Carbohydrate Ligand, sialyl-Lewis X. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6224-8. [2]. L A Lasky, et al. Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation. Science |
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Chemical & Physical Properties
| Density | 1.66g/cm3 |
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| Boiling Point | 1285.8ºC at 760mmHg |
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| Molecular Formula | C31H52N2O23 |
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| Molecular Weight | 820.74400 |
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| Flash Point | 731.4ºC |
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| Exact Mass | 820.29600 |
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| PSA | 410.71000 |
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| Index of Refraction | 1.653 |
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| InChIKey | LAQPKDLYOBZWBT-NYLDSJSYSA-N |
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| SMILES | CC(=O)NC(C=O)C(OC1OC(C)C(O)C(O)C1O)C(OC1OC(CO)C(O)C(OC2(C(=O)O)CC(O)C(NC(C)=O)C(C(O)C(O)CO)O2)C1O)C(O)CO |
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| Storage condition | −20°C |
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| Stability | Store in freezer |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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Articles1
More Articles
| Feizi, T. Curr. Opin. Struct. Biol. 3 , 701, (1993)
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Synonyms
| SLEX,SODIUM SALT |
| S LEX |
| Sialyl Lex tri |
| SSEA 1 |
| 3'-SIALYL-LEWIS-X TETRASACCHARIDE |
| MFCD00270073 |
| Lewis Sugars |
| 3'-SIALYL-LEWISX |
| 3'-SIALYL LEWIS |
