CAS 470-67-7|1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

Introduction：Basic information about CAS 470-67-7|1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles10
7. Synonyms

Common Name	1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane
CAS Number	470-67-7	Molecular Weight	154.249
Density	1.0±0.1 g/cm3	Boiling Point	173.5±8.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₈O	Melting Point	−46 °C(lit.)
MSDS	ChineseUSA	Flash Point	50.7±15.3 °C
Symbol	GHS02	Signal Word	Warning

Names

Name	1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane
Synonym	More Synonyms

BiologicalActivity

Description	1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelResearch Areas >>CancerResearch Areas >>Inflammation/Immunology
References	[1]. Rosazza JP, et al. Microbial hydroxylation of 1,4-cineole. Appl Environ Microbiol. 1987 Oct;53(10):2482-6. [2]. Takaishi M, et al. 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain. 2012 Nov 29;8:86.

Description

1,4-Cineole is a widely distributed, natural, oxygenated monoterpene[1]. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1[2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelResearch Areas >>CancerResearch Areas >>Inflammation/Immunology

References

[1]. Rosazza JP, et al. Microbial hydroxylation of 1,4-cineole. Appl Environ Microbiol. 1987 Oct;53(10):2482-6.

[2]. Takaishi M, et al. 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain. 2012 Nov 29;8:86.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	173.5±8.0 °C at 760 mmHg
Melting Point	−46 °C(lit.)
Molecular Formula	C₁₀H₁₈O
Molecular Weight	154.249
Flash Point	50.7±15.3 °C
Exact Mass	154.135757
PSA	9.23000
LogP	2.58
Vapour Pressure	1.7±0.3 mmHg at 25°C
Index of Refraction	1.491
InChIKey	RFFOTVCVTJUTAD-UHFFFAOYSA-N
SMILES	CC(C)C12CCC(C)(CC1)O2
Storage condition	-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS9274000

CHEMICAL NAME :: p-Menthane, 1,4-epoxy-

CAS REGISTRY NUMBER :: 470-67-7

BEILSTEIN REFERENCE NO. :: 0104974

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H18-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2327 No. of Facilities: 2350 (estimated) No. of Industries: 29 No. of Occupations: 26 No. of Employees: 38044 (estimated) No. of Female Employees: 9165 (estimated)

Safety Information

Symbol	GHS02
Signal Word	Warning
Hazard Statements	H226
Precautionary Statements	P210-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Risk Phrases	R10
Safety Phrases	S16
RIDADR	UN 1993 3/PG 3
WGK Germany	2
RTECS	OS9274000
Packaging Group	III
Hazard Class	3.2

Articles10

Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves.

Life Sci. 92(6-7) , 359-67, (2013)

Transient receptor potential (TRP) vanilloid-1 (TRPV1) and melastatin-8 (TRPM8) channels play a role in transmitting sensory information in primary-afferent neurons. TRPV1 agonists at high concentrati...

1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.

Mol. Pain 8 , 86, (2012)

Essential oils are often used in alternative medicine as analgesic and anti-inflammatory remedies. However, the specific compounds that confer the effects of essential oils and the molecular mechanism...

[Analysis of the chemical constituents of essential oil from Chimonanthus zhejiangensis by GC-MS].

Zhong Yao Cai 33(3) , 385-7, (2010)

To analyze the chemical constituents of the essential oil from Chimonanthus zhejiangensis.Steam distillation was employed to extract volatile compounds of essential oil from Chimonanthus zhejiangensis...

Synonyms

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

Isocineole

1,4-Cineole (natural)

MFCD00209502

1-isopropyl-4-methyl-7-oxa-bicyclo[2.2.1]heptane

1-(2-methylethyl)-4-methyl-7-oxabicyclo[2.2.1]heptane

1,4-EPOXY-P-MENTHANE

1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane

7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-

1,4-Cineol

1,4-Cineole

FEMA No. 3658

p-Menthane,1,4-epoxy

EINECS 207-428-9

p-Menthane, 1,4-epoxy

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