CAS 92623-85-3|(-)-Milnacipran

Introduction：Basic information about CAS 92623-85-3|(-)-Milnacipran, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (-)-Milnacipran BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	(-)-Milnacipran
CAS Number	92623-85-3	Molecular Weight	246.348
Density	1.1±0.1 g/cm3	Boiling Point	393.0±21.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₂N₂O	Melting Point	228-228.5ºC
MSDS	/	Flash Point	191.5±22.1 °C

Names

Name	milnacipran hydrochloride
Synonym	More Synonyms

(-)-Milnacipran BiologicalActivity

Description	Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.Target: SNRIMilnacipran (Ixel, Savella, Dalcipran, Toledomin) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. It is not approved for the clinical treatment of major depressive disorder in the USA, but it is in other countries.Milnacipran inhibits the reuptake of serotonin and norepinephrine in an approximately 1:3 ratio, respectively; in practical use this means a relatively balanced action upon bothneurotransmitters. Increasing both neurotransmitters concentration simultaneously works synergistically to treat both depression and fibromyalgia. Milnacipran exerts no significant actions onH1, α1, D1, D2, and mACh receptors, as well as on benzodiazepine and opioid binding sites. Milnacipran is well absorbed after oral dosing and has a bioavailability of 85%. Meals do not have an influence on the rapidity and extent of absorption. Peak plasma concentrations are reached 2 hours after oral dosing. The elimination half-life of 8 hours is not increased by liver impairment and old age, but by significant renal disease. Milnacipran is conjugated to the inactive glucuronide and excreted in the urine as unchanged drug and conjugate. Only traces of active metabolites are found.
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Serotonin TransporterResearch Areas >>Neurological DiseaseNatural Products >>Others
References	[1]. Moret C, et al. Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology. 1985 Dec;24(12):1211-9. [2]. Briley M, et al. Preclinical pharmacology of milnacipran. Int Clin Psychopharmacol. 1996 Sep;11 Suppl 4:9-14.

Description

Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.Target: SNRIMilnacipran (Ixel, Savella, Dalcipran, Toledomin) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. It is not approved for the clinical treatment of major depressive disorder in the USA, but it is in other countries.Milnacipran inhibits the reuptake of serotonin and norepinephrine in an approximately 1:3 ratio, respectively; in practical use this means a relatively balanced action upon bothneurotransmitters. Increasing both neurotransmitters concentration simultaneously works synergistically to treat both depression and fibromyalgia. Milnacipran exerts no significant actions onH1, α1, D1, D2, and mACh receptors, as well as on benzodiazepine and opioid binding sites. Milnacipran is well absorbed after oral dosing and has a bioavailability of 85%. Meals do not have an influence on the rapidity and extent of absorption. Peak plasma concentrations are reached 2 hours after oral dosing. The elimination half-life of 8 hours is not increased by liver impairment and old age, but by significant renal disease. Milnacipran is conjugated to the inactive glucuronide and excreted in the urine as unchanged drug and conjugate. Only traces of active metabolites are found.

Related Catalog

Signaling Pathways >>Neuronal Signaling >>Serotonin TransporterResearch Areas >>Neurological DiseaseNatural Products >>Others

References

[1]. Moret C, et al. Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology. 1985 Dec;24(12):1211-9.

[2]. Briley M, et al. Preclinical pharmacology of milnacipran. Int Clin Psychopharmacol. 1996 Sep;11 Suppl 4:9-14.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	393.0±21.0 °C at 760 mmHg
Melting Point	228-228.5ºC
Molecular Formula	C₁₅H₂₂N₂O
Molecular Weight	246.348
Flash Point	191.5±22.1 °C
Exact Mass	246.173218
PSA	46.33000
LogP	1.23
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.554

Safety Information

Hazard Codes	Xn: Harmful;
RIDADR	UN 2811 6.1/PG 3

Synonyms

TN-912

MILNACIPRAN

(1R,2S)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide

IXEL

UNII:G56VK1HF36

MIDALCIPRAN

MIDALCIPRAN HYDROCHLORIDE

Milnacipran-d10

Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, (1R,2S)-

MILNACIPRAN HYDROCHL

MILNACIPRAN HCL

TOLEDOMIN

(1R,2S)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide

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