Introduction：Basic information about CAS 65085-01-0|Cefmenoxime, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cefmenoxime |
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| CAS Number | 65085-01-0 | Molecular Weight | 511.55800 |
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| Density | 1.96 g/cm3 | Boiling Point | / |
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| Molecular Formula | C16H17N9O5S3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | cefmenoxime |
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| Synonym | More Synonyms |
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Cefmenoxime BiologicalActivity
| Description | Cefmenoxime (SCE-1365) is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Cefmenoxime (SCE-1365) inhibits at least 90% of strains tested (MIC90) ranged from 0.06 to 8 μg/mL for the Enterobacteriaceae[1]. Cefmenoxime (SCE-1365) inhibits MIC90 values for gram-positive cocci are 0.015 and ≤0.008 μg/mL for Streptococcus pneumoniae and Streptococcus pyogenes, respectively, and 2 μg/mL for S. aureus[1]. Cefmenoxime (SCE-1365) against Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis with MIC90 values ranging from ≤0.008 to 0.25 μg/mL[1]. |
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| In Vivo | Cefmenoxime (SCE-1365) (40 mg/kg; i.h.; daily, for 7 d; male Jcl:ICR mice) improves the survival rate of mice infected with lung bacteria[2]. Animal Model: Male Jcl:ICR mice[2] Dosage: 40 mg/kg Administration: Subcutaneous injection; daily, for 7 days Result: Inhibited mortality rate of animals was 60% at a dose of 40 mg/kg. |
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| References | [1]. Stamm JM, et, al. Antimicrobial activity of cefmenoxime (SCE-1365). Antimicrob Agents Chemother. 1981 Mar;19(3):454-60. [2]. Tatara O, et, al. Synergistic effects of romurtide and cefmenoxime against experimental Klebsiella pneumonia in mice. Antimicrob Agents Chemother. 1992 Jan;36(1):167-71. |
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Chemical & Physical Properties
| Density | 1.96 g/cm3 |
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| Molecular Formula | C16H17N9O5S3 |
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| Molecular Weight | 511.55800 |
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| Exact Mass | 511.05100 |
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| PSA | 269.65000 |
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| LogP | 0.04020 |
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| InChIKey | HJJDBAOLQAWBMH-NOZJJQNGSA-N |
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| SMILES | CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nnnn3C)CSC12)c1csc(N)n1 |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R41:Risk of serious damage to eyes. |
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| Safety Phrases | S26-S39 |
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Synonyms
| Cefmenoxime |
| 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,(6R,7R) |
| (6R,7R)-7-[[(Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| SCE 1365 |
| 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[[1-methyl-1H-tetrazol-5-yl]thiomethyl]-3-cephem-4-carboxylic acid |
| MFCD00864851 |
| CMX |
