Introduction：Basic information about CAS 329196-48-7|SANT-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SANT-2 |
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| CAS Number | 329196-48-7 | Molecular Weight | 479.95500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C26H26ClN3O4 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide |
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| Synonym | More Synonyms |
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SANT-2 BiologicalActivity
| Description | SANT 2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Stem Cell/Wnt >>Hedgehog |
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| References | [1]. Büttner A, et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem. 2009 Jul 15;17(14):4943-54. |
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Chemical & Physical Properties
| Molecular Formula | C26H26ClN3O4 |
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| Molecular Weight | 479.95500 |
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| Exact Mass | 479.16100 |
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| PSA | 85.47000 |
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| LogP | 6.40470 |
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| InChIKey | VQOJFGFKIVFMDH-UHFFFAOYSA-N |
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| SMILES | CCOc1cc(C(=O)Nc2ccc(Cl)c(-c3nc4ccccc4[nH]3)c2)cc(OCC)c1OCC |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Statements | H413 |
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| RIDADR | NONH for all modes of transport |
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Synonyms
