CAS 32988-50-4|Viomycin

Introduction：Basic information about CAS 32988-50-4|Viomycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Viomycin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Viomycin
CAS Number	32988-50-4	Molecular Weight	685.69000
Density	1.8g/cm3	Boiling Point	695.81°C (rough estimate)
Molecular Formula	C₂₅H₄₃N₁₃O₁₀	Melting Point	280°C (lit.)
MSDS	/	Flash Point	/

Names

Name	viomycin
Synonym	More Synonyms

Viomycin BiologicalActivity

Description	Viomycin is a potent antibiotic against Mycobacteria. Viomycin rapidly inhibits polypeptide chain elongation when added to purified endogenous Escherichia coli polysomes actively engaged in polypeptide synthesis[1][2].
Related Catalog	Research Areas >>Cancer
References	[1]. FINLAY AC, et al. Viomycin a new antibiotic active against Mycobacteria. Am Rev Tuberc. 1951 Jan;63(1):1-3. [2]. Modolell J, Vázquez. The inhibition of ribosomal translocation by viomycin. Eur J Biochem. 1977 Dec;81(3):491-7.

Description

Viomycin is a potent antibiotic against Mycobacteria. Viomycin rapidly inhibits polypeptide chain elongation when added to purified endogenous Escherichia coli polysomes actively engaged in polypeptide synthesis[1][2].

Related Catalog

Research Areas >>Cancer

References

[1]. FINLAY AC, et al. Viomycin a new antibiotic active against Mycobacteria. Am Rev Tuberc. 1951 Jan;63(1):1-3.

[2]. Modolell J, Vázquez. The inhibition of ribosomal translocation by viomycin. Eur J Biochem. 1977 Dec;81(3):491-7.

Chemical & Physical Properties

Density	1.8g/cm3
Boiling Point	695.81°C (rough estimate)
Melting Point	280°C (lit.)
Molecular Formula	C₂₅H₄₃N₁₃O₁₀
Molecular Weight	685.69000
Exact Mass	685.32600
PSA	392.86000
Index of Refraction	1.762
InChIKey	HMKHTQGEDRQEOM-IGZVKJTASA-N
SMILES	NCCCC(N)CC(=O)NC1CNC(=O)C(C2CC(O)N=C(N)N2)NC(=O)C(=CNC(N)=O)NC(=O)C(CO)NC(=O)C(CO)NC1=O.O=S(=O)(O)O.O=S(=O)(O)O
Storage condition	Store at -20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZA3900000

CHEMICAL NAME :: Viomycin

CAS REGISTRY NUMBER :: 32988-50-4

LAST UPDATED :: 199609

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C25-H43-N13-O10

MOLECULAR WEIGHT :: 685.81

WISWESSER LINE NOTATION :: T-16-MVYMV GMV JMV NMVTJ CU1MVZ F1Q I1Q LMV1YZ3Z P- DT6MYMTJ BUM FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1075 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,69,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,69,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1637 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,69,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 7 gm/kg

SEX/DURATION :: female 6-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher information, see OIGZDE. Volume(issue)/page/year: 14,107,1965

Synonyms

Tuberactomycin B

Viomicina

Tuberactinomycin B

VIOMYCIN

Florimycin

(3S)-3,6-diamino-N-[(3S,6Z,9S,12S,15S)-3-[(4S,6R)-2-amino-4-hydroxy-1,4,5,6-tetrahydropyrimidin-6-yl]-6-[(carbamoylamino)methylidene]-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazacyclohexadec-15-yl]hexanamide

Celiomycin

Viomycinum

Viomycine

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